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Sub-series Good Clinical Practice (GCP)
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Oral cavity cancer / Vincent Grégoire / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2014)
Oral cavity cancer : diagnosis, treatment and follow-up - Abstract [printed text] / Vincent Grégoire, Author ; Roos Leroy , Author ; Pauline Heus, Author ; Fleur van de Wetering, Author ; Rob Scholten, Author ; Leen Verleye, Author ; Laurens Carp, Author ; Paul Clement, Author ; Philippe Deron, Author ; Karolien Goffin, Author ; Marc Hamoir, Author ; Esther Hauben, Author ; Kristof Hendrickx, Author ; Sidney Kunz, Author ; Olivier Lenssen, Author ; Sandra Nuytz, Author ; Carl Van Laer, Author ; Jan Vermorken, Author ; Eline Appermont, Author ; Annelies De Prins, Author ; Eline Hebbelinck, Author ; Geert Hommez, Author ; Caroline Vandenbruaene, Author ; Eveline Vanhalewyck, Author ; Joan Vlayen , Author ; Lotty Hooft, Author . - Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre, 2014 . - 20 p. : ill. ; A4. - (KCE Reports. Good Clinical Practice (GCP); 227CS) .
ISSN : D/2014/10.273/57 : € 0,00
Study 2012-04-01
Languages : English (eng)
Descriptors: Indexation
2012-04 ; Head and Neck Neoplasms ; Mouth Neoplasms ; Practice Guideline [Publication type] ; R227
Classification
WE 707 Neoplasms (Head and neck)Contents note: 1. INTRODUCTION 5 -- 2. OBJECTIVES AND SCOPE OF THIS GUIDELINE 5 -- 3. METHODS ... 6 -- 3.1. SYSTEMATIC REVIEW OF THE LITERATURE 6 -- 3.2. FORMULATION OF RECOMMENDATIONS 7 -- 4. CLINICAL RECOMMENDATIONS 9 -- 4.1. DIAGNOSIS AND STAGING 9 -- 4.1.1. Patient information ... 9 -- 4.1.2. Biopsy 9 -- 4.1.3. Conventional imaging techniques 10 -- 4.1.4. PET scan 10 -- 4.1.5. Other staging interventions 10 -- 4.1.6. HPV testing ... 11 -- 4.2. TREATMENT OF PRIMARY NON-METASTATIC ORAL CAVITY CANCER 11 -- 4.2.1. Multidisciplinary treatment 11 -- 4.2.2. Surgical treatment 11 -- 4.2.3. Radiotherapy 12 -- 4.2.4. Induction chemotherapy 13 -- 4.2.5. Reconstructive surgery ... 13 -- 4.2.6. Management of the neck lymph nodes 14 -- 4.2.7. Neck dissection after chemoradiotherapy 14 -- 4.3. HISTOPATHOLOGY ... 15 -- 4.4. TREATMENT OF METASTATIC OR RECURRENT DISEASE NOT ELIGIBLE FOR CURATIVE TREATMENT 15 -- 4.5. LOCOREGIONAL RECURRENCE 16 -- 4.6. FOLLOW-UP 16 -- 4.7. REHABILITATION AND SUPPORTIVE TREATMENT 17 -- 4.7.1. Dental rehabilitation 17 -- 4.7.2. Speech and swallowing rehabilitation 17 -- 4.7.3. Nutritional therapy 18 -- 4.7.4. Psychosocial counselling and support 18 -- 5. IMPLEMENTATION AND UPDATING OF THE GUIDELINE 19 -- 5.1. IMPLEMENTATION 19 -- 5.2. MONITORING THE QUALITY OF CARE 19 -- 5.3. GUIDELINE UPDATE 19 -- POLICY RECOMMENDATIONS 20 Link for e-copy: https://doi.org/10.57598/R227CS Format of e-copy: PDF (383 Kb) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=3404 Copies(0)
Status No copy Oral cavity cancer / Vincent Grégoire / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2014)
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Status No copy Oropharyngeal, hypopharyngeal and laryngeal cancer / Vincent Grégoire / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2015)
Oropharyngeal, hypopharyngeal and laryngeal cancer : diagnosis, treatment and follow-up [printed text] / Vincent Grégoire, Author ; Roos Leroy , Author ; Pauline Heus, Author ; Lotty Hooft, Author ; Fleur van de Wetering, Author ; René Spijker, Author ; Rob Scholten, Author ; Johan Abeloos, Author ; Laurens Carp, Author ; Jan Casselman, Author ; Paul Clement, Author ; Philippe Deron, Author ; Marc Hamoir, Author ; Olivier Lenssen, Author ; Sandra Nuyts, Author ; Carl Van Laer, Author ; Jan Vermorken, Author ; Joan Vlayen , Author . - Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre, 2015 . - 112 p. : ill., ; A4. - (KCE Reports. Good Clinical Practice (GCP); 256C) .
ISSN : D/2015/10.273/105 : € 0,00
Languages : English (eng)
Descriptors: Indexation
2012-04-02 ; Head and Neck Neoplasms ; Laryngeal Neoplasms ; Pharyngeal Neoplasms ; Practice Guideline [Publication type] ; R256
Classification
WE 707 Neoplasms (Head and neck)Contents note: LIST OF ABBREVIATIONS 4 -- -- SCIENTIFIC REPORT 8 -- 1 INTRODUCTION 8 -- 1.1 BACKGROUND 8 -- 1.2 THE NEED FOR A GUIDELINE 9 -- 1.3 SCOPE 9 -- 1.4 REMIT OF THE GUIDELINE 9 -- 1.4.1 Overall objectives 9 -- 1.4.2 Target users of the guideline 9 -- 1.5 STATEMENT OF INTENT 10 -- 1.6 FUNDING AND DECLARATION OF INTEREST 10 -- 2 METHODOLOGY 10 -- 2.1 INTRODUCTION 10 -- 2.2 THE GUIDELINE DEVELOPMENT GROUP 10 2.3 GENERAL APPROACH AND CLINICAL RESEARCH QUESTIONS 11 -- 2.4 LITERATURE SEARCH AND QUALITY APPRAISAL 12 2.5 DATA EXTRACTION 12 -- 2.6 STATISTICAL ANALYSIS 12 -- 2.7 GRADING EVIDENCE 13 -- 2.7.1 Therapeutic research questions 15 -- 2.7.2 Diagnostic research questions 15 -- 2.8 FORMULATION OF RECOMMENDATIONS 15 -- 2.9 EXTERNAL REVIEW 17 -- 2.9.1 Healthcare professionals 17 -- 2.9.2 Patient representatives 18 -- 2.10 FINAL VALIDATION 18 -- 3 CLINICAL RECOMMENDATIONS 19 -- 3.1 DIAGNOSIS AND STAGING 19 -- 3.1.1 Locoregional staging with MRI compared to CT 20 -- 3.1.2 PET scan 22 -- 3.1.3 HPV testing 29 -- 3.2 TREATMENT OF PRIMARY NON-METASTATIC HEAD AND NECK SQUAMOUS CELL CARCINOMA 34 -- 3.2.1 Surgical treatment 34 -- 3.2.2 Radiotherapy 44 -- 3.2.3 Induction chemotherapy 70 -- 3.2.4 Management of the neck lymph nodes 75 -- 3.3 HISTOPATHOLOGY 89 -- 3.4 TREATMENT OF METASTATIC OR RECURRENT DISEASE NOT SUITABLE FOR CURATIVE TREATMENT 90 -- 3.5 SALVAGE TREATMENT 92 -- 3.6 FOLLOW-UP 94 -- 3.7 REHABILITATION AND SUPPORTIVE TREATMENT 95 -- 4 IMPLEMENTATION AND UPDATING OF THE GUIDELINE 96 -- 4.1 IMPLEMENTATION 96 -- 4.1.1 Multidisciplinary approach 96 -- 4.1.2 Patient-centered care 96 -- 4.1.3 Barriers and facilitators for implementation of this guideline 96 -- 4.1.4 Actors of the implementation of this guideline 96 Link for e-copy: https://doi.org/10.57598/R256C Format of e-copy: PDF (799 Kb) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=3711 Copies(0)
Status No copy Oropharyngeal, hypopharyngeal and laryngeal cancer / Vincent Grégoire / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2015)
Oropharyngeal, hypopharyngeal and laryngeal cancer : diagnosis, treatment and follow-up - Summary [printed text] / Vincent Grégoire, Author ; Roos Leroy , Author ; Pauline Heus, Author ; Lotty Hooft, Author ; Fleur van de Wetering, Author ; René Spijker, Author ; Rob Scholten, Author ; Johan Abeloos, Author ; Laurens Carp, Author ; Jan Casselman, Author ; Paul Clement, Author ; Philippe Deron, Author ; Marc Hamoir, Author ; Olivier Lenssen, Author ; Sandra Nuyts, Author ; Carl Van Laer, Author ; Jan Vermorken, Author ; Joan Vlayen , Author . - Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre, 2015 . - 12 p. : ill., ; A4. - (KCE Reports. Good Clinical Practice (GCP); 256CS) .
ISSN : D/2015/10.273/104 : € 0,00
Study 2012-04-02
Languages : English (eng)
Descriptors: Indexation
2012-04-02 ; Head and Neck Neoplasms ; Laryngeal Neoplasms ; Pharyngeal Neoplasms ; Practice Guideline [Publication type] ; R256
Classification
WE 707 Neoplasms (Head and neck)Contents note: FOREWORD 1 -- SUMMARY 2 -- 1. INTRODUCTION 3 -- 2. OBJECTIVES AND SCOPE OF THIS GUIDELINE 3 -- 3. METHODS 4 -- 3.1. SYSTEMATIC REVIEW OF THE LITERATURE 4 -- 3.2. FORMULATION OF RECOMMENDATIONS 5 -- 4. CLINICAL RECOMMENDATIONS 7 -- 4.1. DIAGNOSIS AND STAGING 7 -- 4.2. HPV TESTING 7 -- 4.3. TREATMENT OF PRIMARY NON-METASTATIC HEAD AND NECK SQUAMOUS CELL -- CARCINOMA 8 -- 4.3.1. Surgical treatment 8 -- 4.3.2. Radiotherapy 8 -- 4.3.3. Induction chemotherapy 9 -- 4.3.4. Management of the neck lymph nodes 10 -- 4.4. TREATMENT OF METASTATIC OR RECURRENT DISEASE NOT SUITABLE FOR CURATIVE -- TREATMENT 10 -- 4.5. SALVAGE TREATMENT 10 -- 5. IMPLEMENTATION AND UPDATING OF THE GUIDELINE 11 -- 5.1. IMPLEMENTATION.. 11 -- 5.2. MONITORING THE QUALITY OF CARE 11 -- 5.3. GUIDELINE UPDATE 11 -- RECOMMENDATIONS 12 Link for e-copy: https://doi.org/10.57598/R256CS Format of e-copy: PDF (285 Kb) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=3715 Copies(0)
Status No copy Oropharyngeal, hypopharyngeal and laryngeal cancer / Vincent Grégoire / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2015)
Oropharyngeal, hypopharyngeal and laryngeal cancer : diagnosis, treatment and follow-up -Supplement [printed text] / Vincent Grégoire, Author ; Roos Leroy , Author ; Pauline Heus, Author ; Lotty Hooft, Author ; Fleur van de Wetering, Author ; René Spijker, Author ; Rob Scholten, Author ; Johan Abeloos, Author ; Laurens Carp, Author ; Jan Casselman, Author ; Paul Clement, Author ; Philippe Deron, Author ; Marc Hamoir, Author ; Olivier Lenssen, Author ; Sandra Nuyts, Author ; Carl Van Laer, Author ; Jan Vermorken, Author ; Joan Vlayen , Author . - Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre, 2015 . - 248 p. : ill., ; A4. - (KCE Reports. Good Clinical Practice (GCP); 256S) .
ISSN : D/2015/10.273/106 : € 0,00
Study 2012-04-02
Languages : English (eng)
Descriptors: Indexation
2012-04-02 ; Head and Neck Neoplasms ; Laryngeal Neoplasms ; Pharyngeal Neoplasms ; Practice Guideline [Publication type] ; R256
Classification
WE 707 Neoplasms (Head and neck)Contents note: COMPOSITION OF THE GUIDELINE DEVELOPMENT GROUP 10 -- 1.1. COMPOSITION OF THE GUIDELINE DEVELOPMENT GROUP 10 -- 1.2. COMPOSITION OF THE KCE EXPERT TEAM 10 -- 1.3. EXTERNAL RESEARCHERS INVOLVED IN THE GUIDELINE DEVELOPMENT 11 -- 2. SEARCH STRATEGIES 12 -- 2.1. SEARCH STRATEGY FOR GUIDELINES 12 -- 2.2. SEARCH STRATEGIES FOR SYSTEMATIC REVIEWS 13 -- 2.3. SEARCH STRATEGIES FOR PRIMARY STUDIES 19 -- 2.3.1. RQ1: What is the effectiveness and/or diagnostic outcomes of locoregional staging (i.e. Tand N-staging) with MRI compared to CT in patients with head and neck squamous cell carcinoma 19 -- 2.3.2. RQ2: What is the clinical effectiveness of surgery for patients with early oropharyngeal, hypopharyngeal and laryngealcancer? 25 -- a. Surgery versus non-surgery 25 -- b. Function-sparing surgery versus extensive surgery 25 -- 2.3.3. RQ3: Surgery versus organ / function preservation strategies 32 -- 2.3.4. RQ4: Postoperative (chemo)radiotherapy 35 -- a. Postoperative (chemo)radiotherapy versus no postoperative (chemo)radiotherapy 35 -- b. Postoperative chemoradiotherapy versus postoperative radiotherapy 35 -- 2.3.5. RQ5: Management of the neck lymph nodes 40 -- a. Neck dissection versus no neck dissection 40 -- b. Neck dissection type X versus neck dissection type Y 40 -- 2.3.6. RQ6: Salvage treatment versus no/other treatment 44 -- 2.3.7. RQ7: Altered fractionation radiotherapy versus standard radiotherapy 46 -- 3. QUALITY APPRAISAL 47 -- 3.1. QUALITY APPRAISAL TOOLS 47 -- 3.1.1. Guidelines 47 -- 3.1.2. Systematic reviews 48 -- 3.1.3. Diagnostic accuracy studies 50 -- 3.1.4. Primary studies for therapeutic interventions 52 -- 3.2. GUIDELINES SELECTION AND QUALITY APPRAISAL 54 -- 3.3. STUDY SELECTION AND QUALITY APPRAISAL 55 -- 3.3.1. RQ1-6: Systematic reviews 5 53 -- 3.2. RQ1: What is the effectiveness and/or diagnostic outcomes of locoregional staging (i.e. Tand N-staging) with MRI compared to CT in patients with head and neck squamous cell carcinoma 61 -- 3.3.3. RQ2: What is the clinical effectiveness of surgery for patients with early oropharyngeal, hypopharyngeal and laryngealcancer? 68 -- a. Surgery versus non-surgery 68 -- b. Function-sparing surgery versus extensive surgery 68 -- 3.3.4. RQ3: Surgery versus organ / function preservation strategies 77 -- 3.3.5. RQ4: Postoperative (chemo)radiotherapy 84 -- a. Postoperative (chemo)radiotherapy versus no postoperative (chemo)radiotherapy 84 -- b. Postoperative chemoradiotherapy versus postoperative radiotherapy 84 -- 3.3.6. RQ5: Management of the neck lymph nodes 96 -- a. Neck dissection versus no neck dissection 96 -- b. Neck dissection type X versus neck dissection type Y 96 -- 3.3.7. RQ6: Salvage treatment versus no/other treatment 104 -- 3.3.8. RQ7: Altered fractionation radiotherapy versus standard radiotherapy 110 -- 4. EVIDENCE TABLES BY CLINICAL QUESTION 112 -- 4.1. RQ1: WHAT IS THE EFFECTIVENESS AND/OR DIAGNOSTIC OUTCOMES OF LOCOREGIONAL STAGING (I.E. T- AND N-STAGING) WITH MRI COMPARED TO CT IN PATIENTS WITH HEAD AND NECK SQUAMOUS CELL CARCINOMA 112 -- 4.1.1. Evidence tables of systematic reviews RQ1 112 -- 4.1.2. Evidence tables of observational studies RQ1 114 -- 4.2. RQ2: WHAT IS THE CLINICAL EFFECTIVENESS OF SURGERY FOR PATIENTS WITH EARLY OROPHARYNGEAL, HYPOPHARYNGEAL AND LARYNGEALCANCER? 124 -- a. Surgery versus non-surgery 124 -- b. Function-sparing surgery versus extensive surgery 124 -- 4.2.1. Evidence tables of systematic reviews RQ2a & RQ2b 124 -- 4.2.2. Evidence tables of observational studies RQ2a 129 -- 4.2.3. Evidence tables of observational studies RQ2b 142 -- 4.3. RQ3: SURGERY VERSUS ORGAN / FUNCTION PRESERVATION STRATEGIES 144 -- 4.3.1. Evidence tables of systematic reviews RQ3 144 -- 4.3.2. Evidence tables of RCTs RQ3 146 -- 4.3.3. Evidence tables of observational studies RQ3 151 -- 4.4. RQ4: POSTOPERATIVE (CHEMO)RADIOTHERAPY 162 -- a. Postoperative (chemo)radiotherapy versus no postoperative (chemo)radiotherapy 162 -- 4.4.1. Evidence tables of systematic reviews RQ4a 162 -- 4.4.2. Evidence tables of RCTs RQ4a 162 -- 4.4.3. Evidence tables of observational studies RQ4a 164 -- b. Postoperative chemoradiotherapy versus postoperative radiotherapy 196 -- 4.4.4. Evidence tables of systematic reviews RQ4b 196 -- 4.4.5. Evidence tables of RCTs RQ4b 197 -- 4.4.6. Evidence tables of observational studies RQ4b 211 -- 4.5. RQ5: MANAGEMENT OF THE NECK LYMPH NODES 215 -- a. Neck dissection versus no neck dissection 215 -- 4.5.1. Evidence tables of systematic reviews RQ5a 215 -- 4.5.2. Evidence tables of observational studies RQ5a 217 -- b. Neck dissection type X versus neck dissection type Y 238 -- 4.5.3. Evidence tables of systematic reviews RQ5b 238 -- 4.5.4. Evidence tables of RCTs RQ5b 239 -- 4.5.5. Evidence tables of observational studies RQ5b 241 -- 4.6. RQ6: SALVAGE TREATMENT VERSUS NO/OTHER TREATMENT 251 -- 4.6.1. Evidence tables of systematic reviews RQ6 251 -- 4.6.2. Evidence tables of RCTs RQ6 251 -- 4.6.3. Evidence tables of observational studies RQ6 251 -- 4.7. RQ7: ALTERED FRACTIONATION RADIOTHERAPY VERSUS STANDARD RADIOTHERAPY 259 -- 4.7.1. Evidence tables of systematic reviews RQ7 259 -- 4.7.2. Evidence tables of RCTs RQ7 261 -- 5. SUMMARY OF FINDINGS TABLES AND GRADE PROFILES 269 -- 5.1. RQ1: WHAT IS THE EFFECTIVENESS AND/OR DIAGNOSTIC OUTCOMES OF LOCOREGIONAL STAGING (I.E. T- AND N-STAGING) WITH MRI COMPARED TO CT IN PATIENTS WITH HEAD AND NECK SQUAMOUS CELL CARCINOMA 269 -- 5.2. RQ2: WHAT IS THE CLINICAL EFFECTIVENESS OF SURGERY FOR PATIENTS WITH EARLY OROPHARYNGEAL, HYPOPHARYNGEAL AND LARYNGEAL CANCER? 271 -- a. Surgery versus non-surgery 271 -- 5.2.1. Oropharynx 271 -- 5.2.2. Hypopharynx 272 -- 5.2.3. Larynx 272 -- b. Function-sparing surgery versus extensive surgery 275 -- 5.2.4. Oropharynx 275 -- 5.2.5. Hypopharynx 275 -- 5.2.6. Larynx 276 -- 5.3. RQ3: SURGERY VERSUS ORGAN / FUNCTION PRESERVATION STRATEGIES 277 -- 5.3.1. Oropharynx 277 -- 5.3.2. Hypopharynx 279 -- 5.3.3. Larynx 280 -- 5.4. RQ4: POSTOPERATIVE (CHEMO)RADIOTHERAPY 283 -- a. Postoperative (chemo)radiotherapy versus no postoperative (chemo)radiotherapy 283 -- 5.4.1. Mixed population 283 -- 5.4.2. Oropharynx 284 -- 5.4.3. Hypopharynx 286 -- 5.4.4. Larynx 287 -- B. POSTOPERATIVE CHEMORADIOTHERAPY VERSUS POSTOPERATIVE RADIOTHERAPY 289 -- 5.4.5. Mixed population 289 -- 5.4.6. Oropharynx 292 -- 5.4.7. Hypopharynx 293 -- 5.4.8. Larynx 293 -- 5.5. RQ5: MANAGEMENT OF THE NECK LYMPH NODES 293 -- a. Neck dissection versus no neck dissection 293 -- 5.5.1. Oropharynx 293 -- 5.5.2. Hypopharynx 296 -- 5.5.3. Larynx 298 -- b. Neck dissection type X versus neck dissection type Y 300 -- 5.5.4. Oropharynx 300 -- 5.5.5. Hypopharynx 301 -- 5.5.6. Larynx 301 -- 5.6. RQ6: SALVAGE TREATMENT VERSUS NO/OTHER TREATMENT 305 -- 5.7. RQ7: ALTERED FRACTIONATION RADIOTHERAPY VERSUS STANDARD RADIOTHERAPY 308 -- 5.7.1. Hyperfractionation 308 -- 5.7.2. Accelerated fractionation without dose reduction 310 -- 5.7.3. Accelerated fractionation with dose reduction 314 -- 6. FOREST PLOTS 317 -- 6.1. RQ1: WHAT IS THE EFFECTIVENESS AND/OR DIAGNOSTIC OUTCOMES OF LOCOREGIONAL STAGING (I.E. T- AND N-STAGING) WITH MRI COMPARED TO CT IN PATIENTS WITH HEAD AND NECK SQUAMOUS CELL CARCINOMA 317 -- 6.2. RQ2: WHAT IS THE CLINICAL EFFECTIVENESS OF SURGERY FOR PATIENTS WITH EARLY OROPHARYNGEAL, HYPOPHARYNGEAL AND LARYNGEALCANCER? 317 -- a. Surgery versus non-surgery 317 -- b. Function-sparing surgery versus extensive surgery 317 -- 6.3. RQ3: SURGERY VERSUS ORGAN / FUNCTION PRESERVATION STRATEGIES 317 -- 6.4. RQ4: POSTOPERATIVE (CHEMO)RADIOTHERAPY 317 -- a. Postoperative (chemo)radiotherapy versus no postoperative (chemo)radiotherapy 317 -- b. Postoperative chemoradiotherapy versus postoperative radiotherapy 317 -- 6.5. RQ5: MANAGEMENT OF THE NECK LYMPH NODES 318 -- c. Neck dissection versus no neck dissection 318 -- d. Neck dissection type X versus neck dissection type Y 318 -- 6.6. RQ6: SALVAGE TREATMENT VERSUS NO/OTHER TREATMENT 318 -- 6.7. RQ7: ALTERED FRACTIONATION RADIOTHERAPY VERSUS STANDARD RADIOTHERAPY 319 -- 6.7.1. Hyperfractionation 319 -- 6.7.2. Accelerated fractionation without dose reduction 326 -- 6.7.3. Accelerated fractionation with dose reduction 333 -- 7. EXTERNAL REVIEW 337 -- 7.1. EVALUATION OF THE RECOMMENDATIONS BY THE STAKEHOLDERS 337 -- 8. TNM CLASSIFICATION 342 -- 8.1. CTNM CLINICAL CLASSIFICATION 342 -- 8.1.1. Oropharynx 342 -- 8.1.2. Hypopharynx 343 -- 8.1.3. Larynx 344 -- 8.2. PTNM PATHOLOGICAL CLASSIFICATION 347 -- 8.3. STAGE GROUPING 347 Link for e-copy: https://doi.org/10.57598/R256S Format of e-copy: PDF (3,7 MB) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=3712 Copies(0)
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