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Cost-effectiveness analysis of HPV vaccination of boys in Belgium [printed text] / Nancy Thiry, Author ; Sophie Gerkens , Author ; Justien Cornelis , Author ; Vicky Jespers , Author ; Germaine Hanquet, Author . - Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre, 2019 . - 107 p. : ill., ; A4. - (KCE Reports. Health Technology Assessment (HTA); 308) .
ISSN : D/2019/10.273/13 : € 0,00
Languages : English (eng)

Descriptors:	Indexation 2017-04 ; Costs and Cost Analysis ; Female ; Male ; Papillomavirus Infections ; Papillomavirus Vaccines ; R308 ; Technology Assessment, Biomedical Classification QZ 204 Precancerous conditions. Tumor virus infections
Contents note:	LIST OF FIGURES 4 -- LIST OF TABLES .5 -- LIST OF ABBREVIATIONS 7 -- SCIENTIFIC REPORT .9 -- 1 BACKGROUND .9 -- 1.1 HPV INFECTION AND DISEASE .9 -- 1.2 THE HPV VACCINES 10 -- 1.2.1 Cervarix .11 -- 1.2.2 Gardasil .11 -- 1.2.3 Gardasil 9 .12 -- 2 HPV VACCINATION IN BELGIUM 12 -- 2.1 RECOMMENDATIONS OF HPV VACCINATION 12 -- 2.2 ORGANISATION AND FUNDING 13 -- 2.2.1 NIHDI reimbursement 13 -- 2.2.2 Vaccination programmes .14 -- 2.3 VACCINE UPTAKE 14 -- 3 RESEARCH QUESTIONS .15 -- 4 BURDEN OF HPV DISEASES IN BELGIUM 17 -- 4.1 METHODS 17 -- 4.2 HPV PREVALENCE IN BELGIUM OR IN SIMILAR SETTINGS 17 -- 4.3 BURDEN OF HPV-RELATED CANCERS .18 -- 4.3.1 Cervical cancer .22 -- 4.3.2 Anal cancers 22 -- 4.3.3 Vulvar cancer .22 -- 4.3.4 Vaginal cancer 23 -- 4.3.5 Penile cancer .23 -- 4.3.6 Oropharyngeal cancers .24 -- 4.4 BURDEN OF ANOGENITAL WARTS 25 -- 4.5 OTHER COMPLICATIONS OF HPV INFECTION .26 -- 4.6 GENDER DIFFERENCES IN HPV-RELATED DISEASES 26 -- 5 VACCINE EFFICACY AND SAFETY 27 -- 5.1 METHODS 27 -- 5.2 VACCINE EFFICACY 27 -- 5.2.1 Cervical cancers 29 -- 5.2.2 Anal cancer .31 -- 5.2.3 Vulvar and vaginal cancers .32 -- 5.2.4 Penile cancer .33 -- 5.2.5 Oropharyngeal cancer 34 -- 5.2.6 Anogenital warts 35 -- 5.2.7 Additional results for HPV9 .36 -- 5.3 BRIDGING STUDIES 36 -- 5.4 CROSS-PROTECTION 36 -- 5.5 DURATION OF PROTECTION 37 -- 5.6 EFFICACY OF SHORTER SCHEDULE .37 -- 5.7 COMPARISON ACROSS VACCINES .38 -- 5.8 VACCINE SAFETY .38 -- 6 HERD EFFECTS OF HPV VACCINATION 39 -- 6.1 METHODS 39 -- 6.2 SYSTEMATIC REVIEWS 39 -- 6.3 AUSTRALIA 40 -- 7 HPV VACCINATION OF MALES IN OTHER INDUSTRIALISED COUNTRIES 41 -- 7.1 BOYS .41 -- 7.2 MEN HAVING SEX WITH MEN 44 -- 8.1 METHODS 45 -- 8.2. Technical characteristics, vaccine costs and diseases modelled 46 -- 8.2.2 Vaccine efficacy and duration of protection 48 -- 8.2.3 Outcomes considered 50 -- 8.2.4 Disease burden and HPV attribution fraction .50 -- 8.3.1 Criteria 55 -- 8.3.2 Results 55 -- 8.4.1 What is the cost-effectiveness universal (girls and boys) versus girl-only HPV vaccination for the EMA+ indications? 59 -- 8.4.2 What is the cost-effectiveness of universal (girls and boys) versus girl-only HPV vaccination for all HPV-related diseases? 63 -- 8.4.3 Is extending HPV vaccination to boys more cost-effective than increasing the vaccine uptake in girls? 66 -- 8.4.4 If universal (girls and boys) vaccination is opted for, which vaccine is cost-effective? 68 -- 8.4.5 What is the cost-effectiveness of universal (girls and boys) versus girl-only vaccination using low vaccine prices? 69 -- 8.4.6 What is the impact of the vaccine duration of protection on the incremental costeffectiveness ratio? .70 -- 9 DISCUSSION 72 -- 9.1 CLINICAL ASPECTS .72 -- 9.2 ECONOMIC ASPECTS 73 -- 9.3 OTHER ASPECTS 74 -- 9.4 LIMITATIONS 75 -- 9.5 CONCLUSIONS 76 -- APPENDICES 77 -- REFERENCES .94
Link for e-copy:	https://doi.org/10.57598/R308C
Format of e-copy:	PDF (3,02 Mb)
Record link:	https://kce.docressources.info/index.php?lvl=notice_display&id=4509