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Active ageing and solidarity between generations / Brussels [Belgium] : European Commission (2011)  

Active ageing and solidarity between generations : A statistical portrait of the European Union 2012 [printed text] . - Brussels [Belgium] : European Commission, 2011 . - 141 p. : ill., ; 14,8 x 21 cm. ISBN : 978-92-79-21507-0 : € 0,00 Languages : English (eng) Descriptors: Indexation Aged ; Aged, 80 and over ; European Union ; Health Services for the Aged Classification HN 25 - Statistics. Social indicators. Quality of life Abstract: The European Union's population structure is changing and becoming progressively older – at the beginning of 2010, there were 87 million people aged 65 and over in the EU, more than 17 % of the total population. In response to demographic challenges being faced within Europe, the European Union designated 2012 as the European Year for Active Ageing and Solidarity between Generations. The overall objective of the European Year is to facilitate the creation of an active ageing culture in Europe based on a society for all ages. As Europeans live longer and healthier lives, governments are looking for ways to involve older persons more in society and to keep them active. Eurostat is marking the European Year by publishing this book which contains statistics on topics such as demography, healthcare, pensions, volunteering and adult learning. Link for e-copy: https://ec.europa.eu/eurostat/documents/3217494/5740649/KS-EP-11-001-EN.PDF/1f0b [...] Format of e-copy: PDF [Open Access] Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=4495

Age-related changes in human blood lymphocyte subpopulations / F. Erkeller-Yuksel in The Journal of Pediatrics, 120(1996)2 ([02/01/1996])  

[article] Age-related changes in human blood lymphocyte subpopulations [printed text] / F. Erkeller-Yuksel, Author ; V. Deneys, Author ; B. Yuksel, Author ; I. Hannet, Author ; Frank Hulstaert, Author ; C. Hamilton, Author . - 1996 . - 216-222. Languages : English (eng) in The Journal of Pediatrics > 120(1996)2 [02/01/1996] . - 216-222 Descriptors: Classification W 1 Serials. Periodicals Indexation Adolescent ; Adult ; Aged ; Aging ; Antigens, CD ; Child ; Child, Preschool ; Female ; Fetal Blood ; Humans ; Immunophenotyping ; Infant ; Journal Article ; Leukocyte Count ; Lymphocyte Subsets ; Male ; Middle Aged ; Peer Review ; United States Abstract: Flow cytometric analysis of major lymphocyte populations and their subsets reveals age-related changes in the cellular human immune system. Immunophenotypic markers were evaluated in 110 normal pediatric subjects, divided into groups of newborn infants, infants aged 2 days to 11 months, and children aged 1 to 6 years and 7 to 17 years; results were then compared with those obtained from 101 normal adults aged 18 to 70 years. Comparisons among age groups from newborn infants through adults reveal progressive declines in the absolute numbers of leukocytes, total lymphocytes, and T, B, and natural killer (NK) cells. The percentages of T cells within the total lymphocyte population increase with age, in both CD4+ and CD8+ subsets. Percentages of B and NK cells are higher in newborn infants than in adults. The expression of the activation markers interleukin-2R and HLA-DR on T cells increases with age, as does the NK-associated expression of CD57 on CD8 cells. The proportions of B lymphocytes that coexpress CD5 or CDw78 decrease with age, whereas expression of Leu-8 and CD23 increases. The proportion of CD4 cells bearing the CD45RA and Leu-8 markers is consistently lower in adults than in children. These data may serve as a reference range for studies of pediatric subjects. Link for e-copy: http://www.sciencedirect.com/science/journal/00223476 Format of e-copy: PDF [Requires Subscription] Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=2187 [article]

Age-Specific Search Strategies for Medline / Monika Kastner in Journal of Medical Internet Research, 8(4) ([11/05/2012])  

[article] Age-Specific Search Strategies for Medline [printed text] / Monika Kastner, Author ; Nancy L Wilczynski, Author ; Cindy Walker-Dilks, Author ; Kathleen Ann McKibbon, Author ; Brian R. Haynes, Author . - 2012 . - e25. Languages : English (eng) in Journal of Medical Internet Research > 8(4) [11/05/2012] . - e25 Descriptors: Indexation Adult ; Aged ; Infant, Newborn ; MEDLINE ; Obstetrics ; Pediatrics ; Special queries Abstract: BACKGROUND: Many clinicians and researchers are interested in patients of a specific age (childhood, geriatrics, and so on). Searching for age-specific publications in large bibliographic databases such as Medline is problematic because of inconsistencies in indexing, overlapping age categories, and the spread of the relevant literature over many journals. To our knowledge, no empirically tested age-specific search strategies exist for Medline. OBJECTIVE: We sought to determine the retrieval characteristics of age-specific terms in Medline for identifying studies relevant for five clinical specialties: adult medicine, geriatric medicine, pediatric medicine, neonatal medicine, and obstetrics. METHODS: We compared age-specific search terms and phrases for the retrieval of citations in Medline with a manual hand search of the literature for 161 core health care journals. Six experienced research assistants who were trained and intensively calibrated read all issues of 161 journals for the publishing year 2000. In addition to classifying all articles for purpose and quality, study participants' ages were also recorded. Outcome measures were sensitivity, specificity, precision, and accuracy of single and combination search terms. RESULTS: When maximizing sensitivity, the best sensitivity and specificity achieved with combination terms were 98% and 81.2%, respectively, for pediatric medicine, 96.4% and 55.9% for geriatric medicine, 95.3% and 83.6% for neonatal medicine, 94.9% and 64.5% for adult medicine, and 82% and 97.1% for obstetrics. When specificity was maximized, all disciplines had an expected decrease in sensitivity and an increase in precision. Highest values for optimizing best sensitivity and specificity were achieved in neonatal medicine, 92.5% and 92.6%, respectively. CONCLUSION: Selected single terms and combinations of MeSH terms and textwords can reliably retrieve age-specific studies cited in Medline. Link for e-copy: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794003/ Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=3075 [article]

Alendronate or alfacalcidol in glucocorticoid-induced osteoporosis / R.N. de Nijs in The New England journal of medicine, 355(2006)7 ([08/17/2006])  

[article] Alendronate or alfacalcidol in glucocorticoid-induced osteoporosis [printed text] / R.N. de Nijs, Author ; J.W. Jacobs, Author ; W.F. Lems, Author ; R.F. Laan, Author ; A. Algra, Author ; A.M. Huisman, Author ; E. Buskens, Author ; Chris De Laet , Author . - 2006 . - 675-84. Languages : English (eng) in The New England journal of medicine > 355(2006)7 [08/17/2006] . - 675-84 Descriptors: Classification W 1 Serials. Periodicals Indexation Aged ; Bone Density ; Bone Diseases, Metabolic ; Double-Blind Method ; drug therapy ; Female ; Humans ; Journal Article ; Male ; Middle Aged ; Osteoporosis ; Peer Review ; Spine ; United States Abstract: BACKGROUND: Treatment with glucocorticoids is associated with bone loss starting soon after therapy is initiated and an increased risk of fracture. METHODS: We performed a randomized, double-placebo, double-blind clinical trial of 18 months' duration among patients with a rheumatic disease who were starting glucocorticoids at a daily dose that was equivalent to at least 7.5 mg of prednisone. A total of 201 patients were assigned to receive either alendronate (10 mg) and a placebo capsule of alfacalcidol daily or alfacalcidol (1 microg) and a placebo tablet of alendronate daily. The primary outcome was the change in bone mineral density of the lumbar spine in 18 months; the secondary outcome was the incidence of morphometric vertebral deformities. RESULTS: A total of 100 patients received alendronate, and 101 received alfacalcidol; 163 patients completed the study. The bone mineral density of the lumbar spine increased by 2.1 percent in the alendronate group (95 percent confidence interval, 1.1 to 3.1 percent) and decreased by 1.9 percent in the alfacalcidol group (95 percent confidence interval, -3.1 to -0.7 percent). At 18 months, the mean difference of change in bone mineral density between the two groups was 4.0 percent (95 percent confidence interval, 2.4 to 5.5 percent). Three patients in the alendronate group had a new vertebral deformity, as compared with eight patients in the alfacalcidol group (of whom three had symptomatic vertebral fractures) (hazard ratio, 0.4; 95 percent confidence interval, 0.1 to 1.4). CONCLUSIONS: During this 18-month trial in patients with rheumatic diseases, alendronate was more effective in the prevention of glucocorticoid-induced bone loss than was alfacalcidol. (ClinicalTrials.gov number, NCT00138983 [ClinicalTrials.gov].). Link for e-copy: http://www.nejm.org/doi/pdf/10.1056/NEJMoa053569 Format of e-copy: PDF [Open Access] (230 Kb) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=2159 [article]

An economic evaluation of varicella vaccination in Italian adolescents / Nancy Thiry in Vaccine, 22(2004)27-28 ([09/09/2004])  

[article] An economic evaluation of varicella vaccination in Italian adolescents [printed text] / Nancy Thiry, Author ; Philippe Beutels, Author ; Francesco Tancredi, Author ; A. Zanetti, Author ; Paolo Bonanni, Author ; Giovanni Gabutti, Author ; Pierre Van Damme, Author . - 2004 . - 3546-3562. Languages : English (eng) in Vaccine > 22(2004)27-28 [09/09/2004] . - 3546-3562 Descriptors: Classification W 1 Serials. Periodicals Indexation Adolescent ; Adult ; Age Factors ; Aged ; Chickenpox Vaccine ; Child ; Child, Preschool ; Cost of Illness ; Cost-Benefit Analysis ; Economics ; Encephalitis, Varicella Zoster ; Epidemiology ; Female ; Hospitalization ; Humans ; Italy ; Journal Article ; Male ; Markov Chains ; Mass Immunization ; Middle Aged ; Netherlands ; Peer Review ; prevention and control ; statistics and numerical data [Subheading] Abstract: An economic evaluation was performed to assess five varicella vaccination scenarios targeted to 11-year-old Italian adolescents. The scenarios were: "compulsory vaccination" of all adolescents, recommended vaccination of susceptible adolescents on the basis of an "anamnestic screening", a "blood test" or a combination of both ("both tests") and vaccination of adolescents in the private sector, at the parents' charge ("private vaccination"). Probabilities and unit costs were taken from published sources and experts opinion. The accuracy of the anamnestic screening (81.6% sensitivity and 87.3% specificity) was derived from a separate descriptive study among 344 Italian adolescents. The costs and benefits of each scenario were simulated using a Markov model and cost-effectiveness, budget-impact and cost-benefit analyses were conducted. Of all considered scenarios, "both tests" and "anamnestic screening" were the most appealing options with an estimated net direct cost of 5058 and 8929 per life-year gained (compared to no vaccination) versus 14,693-42,842 for the other scenarios. These two scenarios further resulted in substantial net savings for society (over 600,000 per cohort, BCR: 2.17). The need for a serological confirmation was highly dependent on the sensitivity of the anamnestic screening, which is believed to increase once such a program is launched. For practical considerations, "anamnestic screening" seems to be the most convenient option. Link for e-copy: http://tiny.cc/xktyn Format of e-copy: VDIC IP recognition Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=1773 [article]

Analytical performance and clinical utility of the INNOTEST PHOSPHO-TAU181P assay for discrimination between Alzheimer's disease and dementia with Lewy bodies. / H. Vanderstichele in Clinical chemistry and laboratory medicine, 44(2006)12 ([01/01/2006])  

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AoA Bibliographic Database / Washington [United State] : Administration of Aging (AoA)  

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Being mortal / Atul Gawande / Profile Books (2014)

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CANE - Camberwell Assessment of Need for the Elderly / Martin Orrell / London : Gaskell (2004)

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Comment améliorer l’organisation des soins de santé mentale pour les personnes âgées ? / Jef Adriaenssens / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2018)  

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Comment mieux lutter contre la maltraitance des personnes âgées en Belgique ? / Céline Ricour / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2020)  

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Comment mieux lutter contre la maltraitance des personnes âgées en Belgique ? / Céline Ricour / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2020)  

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Cost Effectiveness of Implantable Cardioverter-Defibrillators for Primary Prevention in a Belgian Context / Mattias Neyt in Applied Health Economics and Health Policy, 6(2008)1 ([10/01/2008])  

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Crossover comparison of efficacy and preference for rizatriptan 10 mg versus ergotamine/caffeine in migraine / S. Christie in European Neurology, 49(2003)01 ([01/01/2003])  

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Dementie / Brussel [Belgique] : Politeia Uitgeverij (2015)

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