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An Introduction to Infectious Disease Modelling / Emilia Vynnycky / Oxford ; Melbourne ; New York : Oxford University Press - OUP (2010)
ISBN : 978-0-19-856576-5 : £ 29,95
Languages : English (eng)
Descriptors: Indexation
Disease Transmission, Infectious ; Handbooks ; HIV Infections ; Influenza, Human ; Models, Theoretical
Classification
WA 110 Prevention and control of communicable diseases. Transmission of infectious diseasesAbstract: * Includes worked examples, together with exercises based on real data and real-life problems
* Contains a glossary of key definitions and abbreviations
* Accessible to the majority of readers as it does not assume advanced mathematical skills
* Accompanied by online files and solutions to exercises
Mathematical models are increasingly being used to examine questions in infectious disease control. Applications include predicting the impact of vaccination strategies against common infections and determining optimal control strategies against HIV and pandemic influenza.
This book introduces individuals interested in infectious diseases to this exciting and expanding area. The mathematical level of the book is kept as simple as possible, which makes the book accessible to those who have not studied mathematics to university level. Understanding is further enhanced by models that can be accessed online, which will allow readers to explore the impact of different factors and control strategies, and further adapt and develop the models themselves.
The book is based on successful courses developed by the authors at the London School of Hygiene and Tropical Medicine. It will be of interest to epidemiologists, public health researchers, policy makers, veterinary scientists, medical statisticians and infectious disease researchers.Contents note: Preface -- Abbreviations and Glossary -- 1: Introduction: the basics - infections, transmission and models -- 2: How are models set up? I. An introduction to difference equations -- 3: How are models set up? II. An introduction to differential equations -- 4: What do models tell us about the dynamics of infections? -- 5: Age patterns -- 6: An introduction to stochastic modelling -- 7: How do models deal with contact patterns? -- 8: Sexually transmitted infections -- 9: Special topics in infectious disease modelling -- Appendix -- Basic maths -- Further reading -- Useful equations Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=1979 Hold
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Barcode Call number Media type Location Section Status 10273-02088 WA 110 / VYN Book KCE Library (10.124) Due for return by 12/07/2018 Readers who borrowed this document also borrowed:
SAS/STAT 9.1 Organisatie van de gezondheidszorg Callens, Stefaan Evidence synthesis for decision making in healthcare Sutton, Alexander Applied spatial statistics for public health data Waller, Lance A. Decision Modelling for Health Economic Evaluation Briggs, Andrew H. Determinants of nonadherence to a single-dose nevirapine regimen for the prevention of mother-to-child HIV transmission in Rwanda / T. Delvaux in Journal of acquired immune deficiency syndromes, 50(2009)2 ([02/01/2009])
Languages : English (eng)
in Journal of acquired immune deficiency syndromes > 50(2009)2 [02/01/2009] . - 223-230
Descriptors: Classification
W 1 Serials. Periodicals
Indexation
Adult ; Disease Transmission, Infectious ; drug therapy ; HIV Infections ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; Journal Article ; Patient Compliance ; Peer Review ; Pregnancy ; Pregnancy Complications, Infectious ; Reverse Transcriptase Inhibitors ; Rwanda ; United StatesAbstract: OBJECTIVES: To describe experiences, and identify factors associated with nonadherence to a single-dose nevirapine (SD-NVP) regimen for the prevention of mother-to-child transmission (PMTCT) of HIV in Rwanda.
METHODS: In April to May 2006, using a case-control design at 12 PMTCT sites, we interviewed HIV-infected women who did not adhere (n = 111) and who adhered (n = 125) to the PMTCT prophylaxis regimen. Nonadherence was defined as mother and/or infant not ingesting SD-NVP at the recommended time or not at all and adherence as mother-infant pairs who ingested it as recommended.
RESULTS: Only 61% of nonadherent women had received SD-NVP during pregnancy or delivery. Among nonadherent women who received SD-NVP, 80% ingested it at the recommended time, representing 49% of all nonadherent women. Only 7% of their newborns ingested SD-NVP. Multivariate logistic regression showed that unmarried women, less educated women, women who made 2 or less antenatal care visits, and those offered HIV testing after their first antenatal care visit were more likely to be nonadherent to PMTCT prophylaxis. Not disclosing one's HIV status to someone aside from a partner was also associated with nonadherence in mother-infant pairs.
CONCLUSIONS: Sociodemographic factors, health services delivery factors, and a lack of communication and social support contributed to nonadherence to PMTCT prophylaxis in Rwanda.Link for e-copy: http://www.cebam.be/ Format of e-copy: OVID (via CEBAM - personal login recquired) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=2124 [article]
Languages : English (eng)
in American Journal of Tropical Medicine and Hygiene > 62(2002)4 [04/01/2000] . - 496-501
Descriptors: Classification
W 1 Serials. Periodicals
Indexation
Adult ; Age Factors ; Cross-Sectional Studies ; Epidemiology ; Female ; Haiti ; HIV Infections ; Humans ; Journal Article ; Male ; Peer Review ; Poverty Areas ; Pregnancy ; Prevalence ; Questionnaires ; Risk Factors ; Rural Population ; Sexual Partners ; Sexually Transmitted Diseases ; Socioeconomic Factors ; statistics and numerical data [Subheading] ; United StatesAbstract: A study was conducted to determine the prevalence rate and risk factors for sexually transmitted diseases (STDs) in Haiti's rural Artibonite Valley. Women attending antenatal services at Hospital Albert Schweitzer from October to December 1996 were tested for gonorrhea, chlamydia, trichomonas, syphilis, and human immunodeficiency virus (HIV). Of the 476 women tested, 121 (25.4%) had trichomonas, 11/475 (2.3%) had gonorrhea, 51/475 (10.7%) had chlamydia, 32/474 (6.8%) were seropositive for syphilis, 20/469 (4.3%) were seropositive for HIV, and 191 (40.1%) had at least one STD. Nearly 30% of the women reported having entered a sexual relationship out of economic necessity and had increased odds of HIV infection, Odds Ratio (OR) 6.3 (P < 0.001). We postulate that due to recent economic hardship in rural Haiti, women are entering into sexual relationships out of economic necessity and that this trend is contributing to the growing HIV epidemic. We recommend STD prevention and development programs that target young people and economically disadvantaged women. Link for e-copy: http://www.ajtmh.org/cgi/reprint/62/4/496 Format of e-copy: PDF [Open Access] (Embargo 1 years) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=2066 [article]
Languages : English (eng)
in AIDS > 6(1992)8 [08/01/1992] . - 793-7
Descriptors: Classification
W 1 Serials. Periodicals
Indexation
Antigens, CD ; Antigens, Differentiation ; Fluorescent Antibody Technique ; HIV Infections ; Humans ; Journal Article ; Membrane Glycoproteins ; Peer Review ; T-Lymphocytes ; United StatesAbstract: OBJECTIVE: To study the expression of the activation markers human leukocyte antigen (HLA)-DR and CD38 antigen on CD8+ T-lymphocytes in HIV-infected subjects and HIV-negative controls.
DESIGN: Two- and three-colour flow-cytometric analysis.
METHODS: Fresh peripheral venous blood was obtained from 16 HIV-infected subjects, representing four different stages of HIV disease, and from six HIV-negative controls. Three-colour lymphocyte immunophenotyping was performed using peridinyl chlorophyll-A protein (PerCP)-conjugated anti-CD8 monoclonal antibody (MAb) in combination with anti-HLA-DR (phycoerythrin) and anti-CD38 (fluorescein isothiocyanate) MAb.
RESULTS: The relative percentage of the lymphocyte populations thus defined differed between HIV-negative and HIV-positive subjects and between HIV-infected subjects at different clinical stages of disease. Simultaneous expression of HLA-DR and CD38 within the CD8 T-lymphocyte compartment increased from 8% in controls to 49% in asymptomatic HIV-infected subjects (P less than 0.005). Symptomatic patients differed from asymptomatic seropositives by a further increase in the HLA-DR+ CD38+ CD8 subset. In AIDS patients, the HLA-DR+ CD38- CD8 subset decreased (P less than 0.05) and the HLA-DR- CD38+ CD8 subset increased (P less than 0.05), compared with the other HIV disease stage patients.
CONCLUSION: There is a stage-associated pattern of HLA-DR and CD38 expression on CD8 T-lymphocytes during HIV infection; specific phenotypic patterns may have functional correlates in the host response to the virus.Link for e-copy: http://journals.lww.com/aidsonline/Abstract/1992/08000/Expression_of_activation_ [...] Format of e-copy: IP recognition ((via CEBAM - personal login recquired) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=2202 [article]
Acta Academica 2006 supplement 1
Languages : English (eng)
Descriptors: Classification
WC 503.2 Acquired Immunodeficiency Syndrome. HIV Infections -- Therapy
Indexation
Africa ; Anti-Retroviral Agents ; Health Services Accessibility ; HIV Infections ; Public SectorRecord link: https://kce.docressources.info/index.php?lvl=notice_display&id=546 Hold
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Barcode Call number Media type Location Section Status 10273-00672 WC 503.2/VAN Journal KCE Library (10.124) Available
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