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Age-related changes in human blood lymphocyte subpopulations / F. Erkeller-Yuksel in The Journal of Pediatrics, 120(1996)2 ([02/01/1996])
[article] Age-related changes in human blood lymphocyte subpopulations [printed text] / F. Erkeller-Yuksel, Author ; V. Deneys, Author ; B. Yuksel, Author ; I. Hannet, Author ; Frank Hulstaert, Author ; C. Hamilton, Author . - 1996 . - 216-222.
Languages : English (eng)
in The Journal of Pediatrics > 120(1996)2 [02/01/1996] . - 216-222
W 1 Serials. Periodicals
Adolescent ; Adult ; Aged ; Aging ; Antigens, CD ; Child ; Child, Preschool ; Female ; Fetal Blood ; Humans ; Immunophenotyping ; Infant ; Journal Article ; Leukocyte Count ; Lymphocyte Subsets ; Male ; Middle Aged ; Peer Review ; United States
Abstract: Flow cytometric analysis of major lymphocyte populations and their subsets reveals age-related changes in the cellular human immune system. Immunophenotypic markers were evaluated in 110 normal pediatric subjects, divided into groups of newborn infants, infants aged 2 days to 11 months, and children aged 1 to 6 years and 7 to 17 years; results were then compared with those obtained from 101 normal adults aged 18 to 70 years. Comparisons among age groups from newborn infants through adults reveal progressive declines in the absolute numbers of leukocytes, total lymphocytes, and T, B, and natural killer (NK) cells. The percentages of T cells within the total lymphocyte population increase with age, in both CD4+ and CD8+ subsets. Percentages of B and NK cells are higher in newborn infants than in adults. The expression of the activation markers interleukin-2R and HLA-DR on T cells increases with age, as does the NK-associated expression of CD57 on CD8 cells. The proportions of B lymphocytes that coexpress CD5 or CDw78 decrease with age, whereas expression of Leu-8 and CD23 increases. The proportion of CD4 cells bearing the CD45RA and Leu-8 markers is consistently lower in adults than in children. These data may serve as a reference range for studies of pediatric subjects. Link for e-copy: http://www.sciencedirect.com/science/journal/00223476 Format of e-copy: PDF [Requires Subscription] Record link: [article]Age-related changes in human blood lymphocyte subpopulations / Frank Hulstaert in Clinical immunology and immunopathology, 70(1994)02 ([02/01/1994])
[article] Age-related changes in human blood lymphocyte subpopulations : II. Varying Kinetics of Percentage and Absolute Count Measurements [printed text] / Frank Hulstaert, Author ; I. Hannet, Author ; V. Deneys, Author ; V. Munhyeshuli, Author ; T. Reichert, Author ; M. De Bruyere, Author ; K. Strauss, Author . - 1994 . - 152-158.
Languages : English (eng)
in Clinical immunology and immunopathology > 70(1994)02 [02/01/1994] . - 152-158
W 1 Serials. Periodicals
Adolescent ; Adult ; Aging ; Antigens, CD ; Antigens, Differentiation ; Child ; Child, Preschool ; Female ; Humans ; Immunophenotyping ; Infant ; Infant, Newborn ; Journal Article ; Leukocyte Count ; Male ; Middle Aged ; T-Lymphocytes ; United States
Abstract: A reference range for lymphocyte populations, with particular emphasis on T lymphocyte subsets, was obtained for normal individuals covering age cohorts from birth through adulthood. This report confirms and extends findings from a developmental reference range published earlier (1). Absolute numbers of WBC, lymphocytes, and T, B, and NK subsets decline significantly during childhood. However, differences in the rate of decline of certain lymphocyte subsets leads to discordance between absolute numbers and percentages. Those lymphocyte subsets which decline less rapidly with age than the total lymphocyte count will show an increase in percentage, whereas those which decline more rapidly will show further declines in percentage values. T cell percentages were seen to increase over time whereas B cell percentages decline. Markers of immaturity such as CD45RA on CD4 cells and CD38 on CD8 cells declined in both percentages and absolute numbers. Activation markers, such as HLA-DR on CD8 cells and IL2-R on CD3 cells, increased in percentages with time but changed inconsistently in cell number from infancy to adulthood. These findings extend the lymphocyte references range to markers thought to be informative in various disease states, including HIV infection. Link for e-copy: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WCK-45R79S2-9&_user=1 [...] Format of e-copy: VDIC IP recognition Record link: [article]Age-Specific Search Strategies for Medline / Monika Kastner in Journal of Medical Internet Research, 8(4) ([11/05/2012])
[article] Age-Specific Search Strategies for Medline [printed text] / Monika Kastner, Author ; Nancy L Wilczynski, Author ; Cindy Walker-Dilks, Author ; Kathleen Ann McKibbon, Author ; Brian R. Haynes, Author . - 2012 . - e25.
Languages : English (eng)
in Journal of Medical Internet Research > 8(4) [11/05/2012] . - e25
Adult ; Aged ; Infant, Newborn ; MEDLINE ; Obstetrics ; Pediatrics ; Special queries
Abstract: BACKGROUND: Many clinicians and researchers are interested in patients of a specific age (childhood, geriatrics, and so on). Searching for age-specific publications in large bibliographic databases such as Medline is problematic because of inconsistencies in indexing, overlapping age categories, and the spread of the relevant literature over many journals. To our knowledge, no empirically tested age-specific search strategies exist for Medline.
OBJECTIVE: We sought to determine the retrieval characteristics of age-specific terms in Medline for identifying studies relevant for five clinical specialties: adult medicine, geriatric medicine, pediatric medicine, neonatal medicine, and obstetrics.
METHODS: We compared age-specific search terms and phrases for the retrieval of citations in Medline with a manual hand search of the literature for 161 core health care journals. Six experienced research assistants who were trained and intensively calibrated read all issues of 161 journals for the publishing year 2000. In addition to classifying all articles for purpose and quality, study participants' ages were also recorded. Outcome measures were sensitivity, specificity, precision, and accuracy of single and combination search terms.
RESULTS: When maximizing sensitivity, the best sensitivity and specificity achieved with combination terms were 98% and 81.2%, respectively, for pediatric medicine, 96.4% and 55.9% for geriatric medicine, 95.3% and 83.6% for neonatal medicine, 94.9% and 64.5% for adult medicine, and 82% and 97.1% for obstetrics. When specificity was maximized, all disciplines had an expected decrease in sensitivity and an increase in precision. Highest values for optimizing best sensitivity and specificity were achieved in neonatal medicine, 92.5% and 92.6%, respectively.
CONCLUSION: Selected single terms and combinations of MeSH terms and textwords can reliably retrieve age-specific studies cited in Medline.
Link for e-copy: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794003/ Record link: [article]An economic evaluation of varicella vaccination in Italian adolescents / Nancy Thiry in Vaccine, 22(2004)27-28 ([09/09/2004])
[article] An economic evaluation of varicella vaccination in Italian adolescents [printed text] / Nancy Thiry, Author ; Philippe Beutels, Author ; Francesco Tancredi, Author ; A. Zanetti, Author ; Paolo Bonanni, Author ; Giovanni Gabutti, Author ; Pierre Van Damme, Author . - 2004 . - 3546-3562.
Languages : English (eng)
in Vaccine > 22(2004)27-28 [09/09/2004] . - 3546-3562
W 1 Serials. Periodicals
Adolescent ; Adult ; Age Factors ; Aged ; Chickenpox Vaccine ; Child ; Child, Preschool ; Cost of Illness ; Cost-Benefit Analysis ; Economics ; Encephalitis, Varicella Zoster ; Epidemiology ; Female ; Hospitalization ; Humans ; Italy ; Journal Article ; Male ; Markov Chains ; Mass Immunization ; Middle Aged ; Netherlands ; Peer Review ; prevention and control ; statistics and numerical data [Subheading]
Abstract: An economic evaluation was performed to assess five varicella vaccination scenarios targeted to 11-year-old Italian adolescents. The scenarios were: "compulsory vaccination" of all adolescents, recommended vaccination of susceptible adolescents on the basis of an "anamnestic screening", a "blood test" or a combination of both ("both tests") and vaccination of adolescents in the private sector, at the parents' charge ("private vaccination"). Probabilities and unit costs were taken from published sources and experts opinion. The accuracy of the anamnestic screening (81.6% sensitivity and 87.3% specificity) was derived from a separate descriptive study among 344 Italian adolescents. The costs and benefits of each scenario were simulated using a Markov model and cost-effectiveness, budget-impact and cost-benefit analyses were conducted. Of all considered scenarios, "both tests" and "anamnestic screening" were the most appealing options with an estimated net direct cost of 5058 and 8929 per life-year gained (compared to no vaccination) versus 14,693-42,842 for the other scenarios. These two scenarios further resulted in substantial net savings for society (over 600,000 per cohort, BCR: 2.17). The need for a serological confirmation was highly dependent on the sensitivity of the anamnestic screening, which is believed to increase once such a program is launched. For practical considerations, "anamnestic screening" seems to be the most convenient option. Link for e-copy: http://tiny.cc/xktyn Format of e-copy: VDIC IP recognition Record link: [article]Besoin de soins chroniques des personnes âgées de 18 à 65 ans et atteintes de lésions cérébrales acquises / E Lannoo / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2007)
Besoin de soins chroniques des personnes âgées de 18 à 65 ans et atteintes de lésions cérébrales acquises [printed text] / E Lannoo, Author ; David Larmuseau, Author ; W Van Hoorde, Author ; K Ackaert, Author ; Murielle Lona , Author ; Mark Leys, Author ; T de Barsy, Author ; Marijke Eyssen , Author . - Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre, 2007 . - X, 287 p. : ill. ; 30 cm.. - (KCE Reports B. Health Services Research (HSR); 51B) .
ISSN : D/2006/10.273/ : 0
Etude nr 2005-14
Languages : English (eng) French (fre)
2005-14 ; Adult ; Brain Injury, Chronic ; Health Services Needs and Demand ; Long-Term Care ; Middle Aged ; Needs Assessment ; Nervous System Diseases ; R51
WL 300 General works (Include works on brain alone)
Link for e-copy: https://doi.org/10.57598/R51B Format of e-copy: .PDF (1,77 MB) Record link:
Barcode Call number Media type Location Section Status No copyA candidate vaccine based on the hepatitis C E1 protein / Leroux-Roels, G in Vaccine, 22(2004)23-24 ([08/13/2004])
PermalinkCaring, employment and health among adults of working age / Maria-Isabel Farfan-Portet in European Journal of Public Health, 20(2010)1 ([02/01/2010])
PermalinkChronic Obstructive Pulmonary Disease Surveillance --- United States, 1971--2000 / David M. Mannino in Morbidity and Mortality Weekly Report, 51(2002)SS06 ([08/02/2002])
PermalinkChronische zorgbehoeften bij personen met een niet- aangeboren hersenletsel (NAH) tussen 18 en 65 jaar / E Lannoo / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2007)
PermalinkCost-effectiveness of human papillomavirus vaccination in Belgium / Nancy Thiry in International Journal of Technology Assessment in Health Care, 25(2009)2 ([04/01/2009])
PermalinkCrossover comparison of efficacy and preference for rizatriptan 10 mg versus ergotamine/caffeine in migraine / S. Christie in European Neurology, 49(2003)01 ([01/01/2003])
PermalinkCUGE / Ann Van den Bruel in Alcohol and alcoholism, 39(2004)5 ([08/02/2004])
PermalinkDeterminants of nonadherence to a single-dose nevirapine regimen for the prevention of mother-to-child HIV transmission in Rwanda / T. Delvaux in Journal of acquired immune deficiency syndromes, 50(2009)2 ([02/01/2009])
PermalinkDeveloping and measuring a set of process and outcome indicators for breast cancer / Sabine Stordeur in The Breast, 21(2012)03 ([06/01/2012])
PermalinkDistribution and composition of HDL subclasses in students whose parents suffered prematurely from a myocardial infarction in comparison with controls / M. Rosseneu in Atherosclerosis, 63(1987)2-3 ([02/01/1987])