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Age-related changes in human blood lymphocyte subpopulations / F. Erkeller-Yuksel in The Journal of Pediatrics, 120(1996)2 ([02/01/1996])  

[article] Age-related changes in human blood lymphocyte subpopulations [printed text] / F. Erkeller-Yuksel, Author ; V. Deneys, Author ; B. Yuksel, Author ; I. Hannet, Author ; Frank Hulstaert, Author ; C. Hamilton, Author . - 1996 . - 216-222. Languages : English (eng) in The Journal of Pediatrics > 120(1996)2 [02/01/1996] . - 216-222 Descriptors: Classification W 1 Serials. Periodicals Indexation Adolescent ; Adult ; Aged ; Aging ; Antigens, CD ; Child ; Child, Preschool ; Female ; Fetal Blood ; Humans ; Immunophenotyping ; Infant ; Journal Article ; Leukocyte Count ; Lymphocyte Subsets ; Male ; Middle Aged ; Peer Review ; United States Abstract: Flow cytometric analysis of major lymphocyte populations and their subsets reveals age-related changes in the cellular human immune system. Immunophenotypic markers were evaluated in 110 normal pediatric subjects, divided into groups of newborn infants, infants aged 2 days to 11 months, and children aged 1 to 6 years and 7 to 17 years; results were then compared with those obtained from 101 normal adults aged 18 to 70 years. Comparisons among age groups from newborn infants through adults reveal progressive declines in the absolute numbers of leukocytes, total lymphocytes, and T, B, and natural killer (NK) cells. The percentages of T cells within the total lymphocyte population increase with age, in both CD4+ and CD8+ subsets. Percentages of B and NK cells are higher in newborn infants than in adults. The expression of the activation markers interleukin-2R and HLA-DR on T cells increases with age, as does the NK-associated expression of CD57 on CD8 cells. The proportions of B lymphocytes that coexpress CD5 or CDw78 decrease with age, whereas expression of Leu-8 and CD23 increases. The proportion of CD4 cells bearing the CD45RA and Leu-8 markers is consistently lower in adults than in children. These data may serve as a reference range for studies of pediatric subjects. Link for e-copy: http://www.sciencedirect.com/science/journal/00223476 Format of e-copy: PDF [Requires Subscription] Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=2187 [article]

Age-related changes in human blood lymphocyte subpopulations / Frank Hulstaert in Clinical immunology and immunopathology, 70(1994)02 ([02/01/1994])  

[article] Age-related changes in human blood lymphocyte subpopulations : II. Varying Kinetics of Percentage and Absolute Count Measurements [printed text] / Frank Hulstaert, Author ; I. Hannet, Author ; V. Deneys, Author ; V. Munhyeshuli, Author ; T. Reichert, Author ; M. De Bruyere, Author ; K. Strauss, Author . - 1994 . - 152-158. Languages : English (eng) in Clinical immunology and immunopathology > 70(1994)02 [02/01/1994] . - 152-158 Descriptors: Classification W 1 Serials. Periodicals Indexation Adolescent ; Adult ; Aging ; Antigens, CD ; Antigens, Differentiation ; Child ; Child, Preschool ; Female ; Humans ; Immunophenotyping ; Infant ; Infant, Newborn ; Journal Article ; Leukocyte Count ; Male ; Middle Aged ; T-Lymphocytes ; United States Abstract: A reference range for lymphocyte populations, with particular emphasis on T lymphocyte subsets, was obtained for normal individuals covering age cohorts from birth through adulthood. This report confirms and extends findings from a developmental reference range published earlier (1). Absolute numbers of WBC, lymphocytes, and T, B, and NK subsets decline significantly during childhood. However, differences in the rate of decline of certain lymphocyte subsets leads to discordance between absolute numbers and percentages. Those lymphocyte subsets which decline less rapidly with age than the total lymphocyte count will show an increase in percentage, whereas those which decline more rapidly will show further declines in percentage values. T cell percentages were seen to increase over time whereas B cell percentages decline. Markers of immaturity such as CD45RA on CD4 cells and CD38 on CD8 cells declined in both percentages and absolute numbers. Activation markers, such as HLA-DR on CD8 cells and IL2-R on CD3 cells, increased in percentages with time but changed inconsistently in cell number from infancy to adulthood. These findings extend the lymphocyte references range to markers thought to be informative in various disease states, including HIV infection. Link for e-copy: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WCK-45R79S2-9&_user=1 [...] Format of e-copy: VDIC IP recognition Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=2209 [article]

Comment formuler une question pico ? / Ann Van den Bruel in Revue médicale de Liège, 59(2004)11 ([11/01/2004])  

[article] Comment formuler une question pico ? [printed text] / Ann Van den Bruel, Author ; Pierre Chevalier, Author ; E. Vermeire, Author ; Bert Aertgeerts, Author ; F. Buntinx, Author . - 2004 . - 671-675. Languages : French (fre) in Revue médicale de Liège > 59(2004)11 [11/01/2004] . - 671-675 Descriptors: Classification W 1 Serials. Periodicals Indexation Belgium ; Child ; drug therapy ; Evidence-Based Medicine ; Humans ; Infant ; Information Storage and Retrieval ; Journal Article ; Peer Review ; Practice Guideline [Publication type] Abstract: Nous commençons notre série d’articles en abordant une affection couramment rencontrée chez l’enfant en pratique médicale : l’otite moyenne. Sous la pression des parents, des antibiotiques sont souvent prescrits. Le médecin sait que l\'utilité de ce traitement est limitée. Mais il doute : en est-il de même pour un enfant d\'un an et demi ? Pour en être sûr, il va confronter ses connaissances avec ce qui est publié dans la littérature et disponible sur internet. Comment débuter cette recherche ? Dans ce premier article, le médecin découvre comment traduire sa question pratique en une question appelant une réponse, et, ensuite, en une question PICO. Ce dernier aspect permet alors au médecin généraliste de trouver des sources utilisables et pertinentes afin d’apporter une réponse rationnelle et fondée à sa question clinique. Link for e-copy: http://www.rmlg.ulg.ac.be/aboel.php?num_id=1144&langue=FR Format of e-copy: PDF [Open Access] Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=1802 [article]

Convincing or confusing? / Philippe Beutels in Vaccine, 25(2007)8 ([02/09/2007])  

[article] Convincing or confusing? : Economic evaluations of childhood pneumococcal conjugate vaccination [printed text] / Philippe Beutels, Author ; Nancy Thiry, Author ; Pierre Van Damme, Author . - 2007 . - 1355-1367. Research Support, Non-U.S. Gov't Review Languages : English (eng) in Vaccine > 25(2007)8 [02/09/2007] . - 1355-1367 Descriptors: Classification W 1 Serials. Periodicals Indexation Child, Preschool ; Economics ; Humans ; immunology ; Infant ; Journal Article ; Netherlands ; Peer Review ; Pneumococcal Infections ; Pneumococcal Vaccines ; prevention and control ; Vaccines Conjugate Abstract: We review 15 economic analyses of pneumococcal conjugate vaccines, published between 2002 and 2006, in terms of methodology, assumptions, results and conclusions. We found a great diversity in assumptions (eg, vaccine efficacy parameters, incidence rates for both invasive and non-invasive disease) mainly due to local variation in data and opinions. Accordingly, the results varied greatly, from total net savings to over euro 100,000 per discounted QALY gained. The cost of the vaccination program (determined by price per dose and schedule (4 or 3 doses, or fewer)), and likely herd immunity impacts are highly influential though rarely explored in these published studies. If the net long-term impact (determined by a mixture of effects related to herd immunity, serotype replacement, antibiotic resistance and cross reactivity) remains beneficial and if a 3-dose schedule confers near-equivalent protection to a 4-dose schedule, the cost-effectiveness of PCV7 vaccination programs can be viewed as attractive in developed countries. Link for e-copy: http://tiny.cc/aalwe Format of e-copy: VDIC IP recognition Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=1767 [article]

Cost-effectiveness of 10- and 13-valent pneumococcal conjugate vaccines in childhood / Philippe Beutels / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2011)  

Cost-effectiveness of 10- and 13-valent pneumococcal conjugate vaccines in childhood [printed text] / Philippe Beutels, Author ; Adriaan Blommaert, Author ; Germaine Hanquet, Author ; J Bilcke, Author ; Nancy Thiry, Author ; Martine Sabbe, Author ; J. Verhaegen, Author ; F De Smet, Author ; Michael Callens, Author ; Pierre Van Damme, Author . - Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre, 2011 . - VIII, 101 p. : ill. ; A4. - (KCE Reports. Health Technology Assessment (HTA); 155C) . ISSN : D/2011/10.273/21 : € 0,00 Study 2009-52 (HTA): Incremental cost-effectiveness of the 7, 10 and 13-valent pneumococcal conjugate vaccines Languages : English (eng) Descriptors: Classification WC 217 Pneumococcal infections Indexation 2009-52 ; Cost-Benefit Analysis ; Infant ; Pneumococcal Infections ; Pneumococcal Vaccines ; R155 ; Vaccines Conjugate Contents note: LIST OF TABLES 3-- LIST OF FIGURES 5-- GLOSSARY 6-- 1 BACKGROUND 7-- 1.1 THE SEVEN-VALENT CONJUGATE PNEUMOCOCCAL VACCINE 7-- 1.2 TWO NEW CONJUGATE PNEUMOCOCCAL VACCINES 8-- 2 OBJECTIVES AND RESEARCH QUESTIONS 9-- 3 LITERATURE SEARCHES AND METHODS 10-- 4 IMMUNOGENICITY, EFFICACY AND EFFECTIVENESS OF CURRENT-- PNEUMOCOCCAL CONJUGATE VACCINES 13-- 4.1 SEVEN VALENT PNEUMOCOCCAL CONJUGATE VACCINE (PCV7) 13-- 4.1.1 Clinical trials – efficacy of PCV7 13-- 4.1.2 Post-licensure studies – effectiveness of PCV7 14-- 4.1.3 Pathogenicity of serotypes 21-- 4.2 TEN VALENT PNEUMOCOCCAL CONJUGATE VACCINE (PCV10) 22-- 4.2.1 Clinical trials – immunogenicity of PCV10 22-- 4.2.2 Clinical trials – efficacy of PCV10 24-- 4.3 THIRTEEN VALENT PNEUMOCOCCAL CONJUGATE VACCINE (PCV13) 25-- 4.3.1 Clinical trials – immunogenicity of PCV13 25-- 5 DISEASE BURDEN IN BELGIUM 27-- 5.1 INVASIVE PNEUMOCOCCAL DISEASE (IPD) 28-- 5.2 ACUTE OTITIS MEDIA (AOM) AND COMMUNITY ACQUIRED PNEUMONIAE (CAP) 35-- 5.3 HOSPITALISATIONS 36-- 5.3.1 Meningitis hospitalisations 36-- 5.3.2 Bacteremia and septicaemia hospitalisations 38-- 5.3.3 Pneumonia hospitalisations 39-- 5.4 DEATHS 39-- 5.4.1 Invasive pneumococcal diseases (IPD) deaths 39-- 5.4.2 (Pneumococcal) pneumonia deaths 40-- 5.4.3 Pneumococcal meningitis deaths 40-- 5.4.4 Pneumococcal septicaemia deaths 41-- 6 ECONOMIC EVALUATIONS OF PCV10 AND PCV13 42-- 6.1 MODELS STRUCTURE 42-- 6.2 MAIN ASSUMPTIONS AND RESULTS 43-- 7 MATHEMATICAL MODELS OF PNEUMOCOCCAL TRANSMISSION 46-- 8 COST-UTILITY ANALYSIS OF PCV10 AND PCV13 IN BELGIUM 48-- 8.1 STUDY DESIGN 48-- 8.1.1 General 48-- 8.1.2 Vaccination options 48-- 8.1.3 Mathematical model structure 49-- 8.2 MODEL INPUT DATA 50-- 8.2.1 Epidemiological parameters and transition probabilities 50-- 8.2.2 Vaccine efficacy estimates 52-- 8.2.3 Direct costs 61-- 8.2.4 Health-Related Quality of Life 63-- 8.3 RESULTS 64-- 8.3.1 Cost-effectiveness acceptability curves 64-- 8.3.2 Incremental costs, outcomes and cost-effectiveness ratios 68-- 8.3.3 Further scenario analyses 77-- 8.3.4 Influence of vaccine price and of inclusion or exclusion of AOM 77-- 8.3.5 Influence of serotype replacement and herd immunity assumptions 79-- 8.3.6 Joint influence of vaccine price, expected serotype replacement and of the additional-- effectiveness of PCV10 versus PCV13 against otitis media 79-- 8.3.7 Budget impact analysis 82-- 9 CONCLUSION 83-- 10 APPENDICES: ADDITIONAL COST-EFFECTIVENESS ACCEPTABILITY-- CURVES 86-- 11 REFERENCES 88 Link for e-copy: https://doi.org/10.57598/R155C Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=2572

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Een quadrivalent vaccin tegen group B meningokokken / Germaine Hanquet / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2014)  

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Effecten en kosten van de vaccinatie van Belgische kinderen met geconjugeerd pneumococcenvaccin / Philippe Beutels / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2006)  

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Effects and costs of pneumococcal conjugate vaccination of Belgian children / Philippe Beutels / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2006)  

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Effets et coûts de la vaccination des enfants belges au moyen du vaccin conjugué antipneumococcique / Philippe Beutels / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2006)  

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Feeding practices and factors contributing to wasting, stunting, and iron-deficiency anaemia among 3-23-month old children in Kilosa district, rural Tanzania. / P.S. Mamiro in Journal of health, population, and nutrition, 23(2005)3 ([09/01/2005])  

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Geboren worden als Brusselaar / David Hercot / Brussel : Observatorium voor Gezondheid en Welzijn van Brussel-Hoofdstad - Observatoire de la santé et du social Bruxelles (2015)  

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Hospital-acquired, laboratory-confirmed bloodstream infections / France Vrijens in Journal of Hospital Infection, 75(2010)03 ([04/01/2010])  

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Invasive Haemophilus influenzae Disease, Europe, 1996-2006 / S. Ladhani in Emerging Infectious Diseases, 16(2010)03 ([03/01/2010])  

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Iron supplementation in previously anemic Bolivian children normalized hematologic parameters, but not immunologic parameters. / E. Sejas in Journal of Tropical Pediatrics, 54(2008)3 ([06/02/2008])  

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Is the 2000 CDC growth reference appropriate for developing countries? / Dominique Roberfroid in Public Health Nutrition, 9(2006)2 ([04/01/2006])  

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