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Comment mieux lutter contre la maltraitance des personnes âgées en Belgique ? / Céline Ricour / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2020)
Comment mieux lutter contre la maltraitance des personnes âgées en Belgique ? : Synthèse [printed text] / Céline Ricour, Author ; Anja Desomer, Author ; Céline Pouppez, Author ; Célia Primus-de Jong, Author ; Imgard Vinck , Author . - Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre, 2020 . - 54 p. : ill., ; A4. - (KCE Reports B. Health Services Research (HSR); 331BS) .
ISSN : D/2020/10.273/18 : € 0,00
Languages : French (fre)
Descriptors: Indexation
2018-10 ; Aged ; Belgium ; Domestic Violence ; Elder Abuse ; R331
Classification
WA 356 Elder AbuseAbstract: La maltraitance des personnes âgées concernerait une personne sur six de 60 ans ou plus dans le monde. Mais seul un cas sur 24 serait signalé. Dans notre pays, le Centre fédéral d’Expertise des Soins de Santé (KCE) a tenté d’y voir plus clair dans les obstacles qui freinent la détection des situations problématiques et dans les possibilités d’améliorer leur prise en charge. Il publie aujourd’hui un rapport détaillé qui propose, entre autres pistes d’amélioration, un ‘plan par étapes’ qui devrait être mis à la disposition de tous les intervenants potentiels auprès de personnes âgées, pour les guider dans les questions à se poser et les attitudes à adopter face à toute suspicion de maltraitance. Link for e-copy: https://doi.org/10.57598/R331BS Format of e-copy: PDF (1,9 Mb) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=4689 Common Statistical Methods for Clinical Research / Glenn A. Walker / Cary, NC [United States] : SAS Institute (2002)
Common Statistical Methods for Clinical Research [printed text] / Glenn A. Walker, Author . - Cary, NC [United States] : SAS Institute, 2002 . - 488 p.
ISBN : 978-1-59047-040-4 : 62,95 $
Languages : English (eng)
Descriptors: Classification
WA 950 Theory or methods of medical statistics
Indexation
SAS ; StatisticsAbstract: This newly updated second edition provides clinical researchers with an invaluable aid for understanding the statistical methods cited most frequently in clinical protocols, statistical analysis plans, clinical and statistical reports, and medical journals. The text is written in a way that takes the non-statistician through each test using examples, yet substantive details are presented that benefit even the most experienced data analysts. Introductory chapters provide elementary statistical concepts as applied to clinical trials and an overview of statistical inference, including discussions about power, calculating sample size, p-values, and the logic behind hypothesis testing. The statistical methods discussed here represent a composite of methods most commonly used in the analysis of clinical research data. Numerous examples taken from clinical research show how to calculate statistical data both manually and using SAS. This edition includes new sections about crossover designs and multiple comparison methods, a discussion of interim analyses, 50% more examples, and reader exercises. Extensions of methods previously presented only in their most elementary form are shown in new examples. This title is also available in digital format. Contents note: Chapter 1-Introduction & Basics 1.1 Statistics - the Field 1.2 Probability Distributions 1.3 Study Design Features 1.4 Descriptive Statistics 1.5 Inferential Statistics 1.6 Summary
Chapter 2-Topics in Hypothesis Testing / Significance Levels
Power / One-Tailed and Two-Tailed Tests / p-Values / Sample Size Determination / Multiple Testing / Summary Chapter 3-The Data Set TRIAL Introduction / Data Collection / Creating the Data Set TRIAL / Statistical Summarization / Summary Chapter 4-The One-Sample t-Test Introduction / Synopsis / Examples / Details & Notes Chapter 5-The Two-Sample t-Test / Chapter 6-One-Way ANOVA / Chapter 7-Two-Way ANOVA / 8-Repeated Measures Analysis / Chapter 9-The Crossover Design / Chapter 10-Linear Regression /
Chapter 11-Analysis of Covariance / Chapter 12-The Wilcoxon Signed-Rank Test / Chapter 13-The Wilcoxon Rank-Sum Test / Chapter 14-The Kruskal-Wallis Test / Chapter 15-The Binomial Test / Chapter 16-The Chi-Square Test / Chapter 17-Fisher's Exact Test / Chapter 18-McNemar's Test / Chapter 19-The Cochran-Mantel-Haenszel Test / Chapter 20-Logistic Regression /
Chapter 21-The Log-Rank Test / Chapter 22-The Cox Proportional / Chapter 23-Exercises / Appendix A - Probability Tables
Probabilities of the Standard Normal Distribution / Critical Values of the Student / Critical Values of the Chi-Square Distribution / Appendix B - Common Distributions Used in Statistical Inference / Notation / Properties / Results
Distributional Shapes / Appendix C - Basic ANOVA Concepts
Within- vs. Between-Group Variation / Noise Reduction by Blocking / Least Squares Mean (LS-mean) /Appendix D - SS Types I, II, III, and IV Methods for an Unbalanced Two-Way Layout
SS Types Computed by SAS / How to Determine the Hypothesis Tested / Empty Cells / More Than Two Treatment Groups
Summary / Appendix E - Multiple Comparison Methods
Multiple Comparisons of Means / Multiple Comparisons of Binomial Proportions / Summary / Appendix F - Data Transformations / Introduction / The Log Transformation
Appendix G - SAS Code for Exercises in Chapter 23 / References
IndexRecord link: https://kce.docressources.info/index.php?lvl=notice_display&id=137 Hold
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Barcode Call number Media type Location Section Status 10273-00210 WA950/WAL Book KCE Library (10.124) Available Readers who borrowed this document also borrowed:
Epidemiology Rothman, Kenneth J. Epidemiology Woodward, Mark Categorical data analysis Agresti, Alan Applied survey data analysis Heeringa, Steven Models for discrete longitudinal data Molenberghs, Geert SAS Procedures Guide SAS Institute Applied spatial statistics for public health data Waller, Lance A. PROC TABULATE by example Haworth, Lauren E. Survival analysis using the SAS system Allison, Paul David Step-by-Step Programming with Base SAS Software SAS Institute Modern epidemiology Rothman, Kenneth J. Compendium gezondheidszorg en -statistiek / Henri Vanden Baviére / Mechelen, Brussel : Kluwer (2003)
Compendium gezondheidszorg en -statistiek : Gezondheids-, ouderen- en thuiszorg: de cijfers en het verhaal erachter [printed text] / Henri Vanden Baviére, Editor ; Walter Sermeus ; Rudy Van Tielen, Author ; Paul Gemmel ; Krist'l Krols ; Dirk Corens . - Mechelen, Brussel : Kluwer, 2003.
ISSN : 163
Languages : Dutch (dut)
Descriptors: Classification
WA 900 Public health statistics (including narrative reports on health conditions and health surveys)Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=100 Hold
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Barcode Call number Media type Location Section Status 10273-00163 WA 900/VAN Book KCE Library (10.124) Available Competences for the organisation of health care, health promotion, prevention and well being in Belgian prisons / Imgard Vinck / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2017)
Competences for the organisation of health care, health promotion, prevention and well being in Belgian prisons : Health care in Belgian prisons - Chapter 7 [printed text] / Imgard Vinck , Author ; Patriek Mistiaen , Author . - Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre, 2017 . - 14 p. : ill., ; A4. - (KCE Reports. Health Services Research (HSR); 293C7) .
Health care in Belgian prisons / Patriek Mistiaen / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2017)
ISSN : D/2017/10.273/72 : € 0,00
Languages : English (eng)
Descriptors: Indexation
2015-50 ; Criminals ; Health Services Research ; Healthcare Financing ; Insurance, Health ; Legislation as topic ; Prisoners ; Prisons ; R293
Classification
WA 300 Health issues of special population groupsContents note: 1 INTRODUCTION 3 -- 2 POLICY RELATED TO HEALTH PROMOTION, PREVENTION AND WELLBEING IN THE FLEMISH COMMUNITY 6 -- 2.1 STRATEGIC PLAN HELP AND ASSISTANCE TO PRISONERS 6 -- 3 INSTANCES OFFERING SERVICES RELATED TO HEALTH PROMOTION, PREVENTION AND WELLBEING IN THE FLEMISH COMMUNITY 8 -- 3.1 INSTANCES OFFERING OVERALL PSYCHO-SOCIAL ASSISTANCE 8 -- 3.2 INSTANCES OFFERING CARE IN A SPECIFIC DOMAIN 8 -- 3.3 SCREENING FOR CONTAGIOUS DISEASES IN PRISON 8 -- 3.4 DRUGS POLICY AND DRUGS PROGRAMS 9 -- 3.4.1 Substitution treatment 9 -- 3.4.2 Harm reduction Interventions 9 -- 3.4.3 Program ‘B.Leave’ in Ruiselede 9 -- 3.4.4 Drug free wings in Bruges and Hasselt 10 -- 3.4.5 Central Registration Points (CRPs) 10 -- 4 ORGANISATION AND COORDINATION IN PRISONS IN BRUSSELS 11 -- 5 POLICY AND INSTANCES OFFERING SERVICES RELATED TO HEALTH PROMOTION, PREVENTION AND WELLBEING IN THE FÉDÉRATION WALLONIE - BRUXELLES 13 -- 5.1 SERVICES RELATED TO HEALTH PROMOTION, PREVENTION AND WELLBEING 13 -- 6 CONCLUSION 14 Link for e-copy: http://doi.org/10.57598/R293C7 Format of e-copy: PDF (451 Kb) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=4228 Compulsory licensing for expensive medicines / Esther Van Zimmeren / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2022)
Compulsory licensing for expensive medicines [printed text] / Esther Van Zimmeren, Author ; Timo Minssen, Author ; Liesbet Paemen, Author ; Walter Van Dyck, Author ; Jeroen Luyten, Author ; Rosanne Janssens, Author ; Liese Barbier, Author ; Simoens, Steven, Author ; Céline Pouppez, Author ; Irina Cleemput , Author ; Imgard Vinck , Author . - Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre, 2022 . - p.1-119; P1-64; P1-4 : ill., ; A4. - (KCE Reports. Health Services Research (HSR); 356) .
ISSN : D/2022/10.273/35 : € 0,00
Languages : English (eng)
Descriptors: Indexation
2020-50 ; Intellectual Property[MeSH Terms] Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014); Legislation, Drug ; Legislation, Pharmacy
Year introduced: 1996[MeSH Terms] Laws and regulations, pertaining to the field of pharmacy, proposed for enactment or enacted by a legislative body.; Patent
Year introduced: 1968[MeSH Terms] Work consisting of documents granted by a government giving exclusive rights to an inventor or assignee to manufacture, use, or sell an invention for a certain number of years.; Pharmaceutical Preparations ; R356
Year introduced: 2008(1999)
Classification
WA 32 LegislationContents note: Part 1 – Legal study
1 INTRODUCTION 9 -- 2 THE PHARMACEUTICAL SECTOR: TRENDS, PRACTICES AND CHARACTERISTICS OF THE LEGAL AND GOVERNANCE FRAMEWORK 12 -- 2.1 INTRODUCTION .12 -- 2.2 KEY STAKEHOLDERS & INNOVATION TRENDS IN THE PHARMACEUTICAL SECTOR 12 -- 2.3 CHARACTERISTICS RELEVANT LEGAL FRAMEWORK PHARMACEUTICAL SECTOR 14 -- 2.4 COSTS OF R&D, BUSINESS AND IP STRATEGIES .15 -- 3 KEY PATENT LAW PRINCIPLES AND THE PHARMACEUTICAL SECTOR .19 -- 3.1 INTRODUCTION .19 -- 3.2 THE NATURE OF PATENT RIGHTS AND THE PATENT RATIONALE 19 -- 3.3 PATENT APPLICATION PROCEDURES 21 -- 3.4 KEY PATENTABILITY CRITERIA AND PATENTING PRACTICES IN THE PHARMACEUTICAL SECTOR 23 -- 3.5 EXCEPTIONS TO PATENT RIGHTS RELEVANT FOR THE PHARMACEUTICAL SECTOR 28 -- 3.6 INTERIM CONCLUSION .31 -- 4 LEGAL AND GOVERNANCE FRAMEWORK FOR REGULATORY EXCLUSIVITIES AND TRANSPARENCY OF CLINICAL TRIALS DATA 33 -- 4.1 INTRODUCTION .33 -- 4.2 THE INTERNATIONAL AND EUROPEAN LEGAL AND GOVERNANCE FRAMEWORK RELATED TO REGULATORY EXCLUSIVITIES 34 -- 4.2.1 The International Legal Framework for Regulatory Exclusivities: TRIPs Agreement 34 -- 4.2.2 The European Legal Framework for Regulatory Exclusivities 34 -- 4.2.3 Trends, Business and Legal Practices regarding Regulatory Exclusivities 40 -- 4.3 LEGAL AND GOVERNANCE FRAMEWORK RELATED TO CTD TRANSPARENCY 43 -- 4.3.1 Introduction .43 -- 4.3.2 European Legal Framework for Clinical Trial Data Transparency 44 -- 4.3.3 Trends, Business and Legal Practices regarding Clinical Trials Transparency 45 -- 4.4 INTERIM CONCLUSION .48 -- 5 COMPULSORY LICENSING 49 -- 5.1 INTRODUCTION .49 -- 5.2 THE INTERNATIONAL AND EUROPEAN LEGAL AND POLICY FRAMEWORK FOR COMPULSORY LICENSING 50 -- 5.2.1 CLs & the International Legal Framework: Paris Convention and TRIPs Agreement 50 -- 5.2.2 CLs & the European Legal and Policy Framework: The EU Biotechnology Directive and the Unitary Patent Package, the EC Action Plan and Competition Law 59 -- 5.3 THE BELGIAN LEGAL FRAMEWORK FOR CLS .71 -- 5.3.1 Current Belgian Legal Framework for CLs .71 -- 5.3.2 CLs and Import to Belgium .74 -- 5.3.3 Legislative Proposal CLs .75 -- 5.3.4 Recommendations regarding the CL Mechanism for Public Health in Belgium and the Legislative Proposal for Excessive Pricing .78 -- 5.4 CLS FOR PUBLIC HEALTH & EXCESSIVELY PRICED MEDICINES IN OTHER COUNTRIES .80 -- 5.4.1 Key CL Mechanisms 81 -- 5.5 CLS FOR PUBLIC HEALTH & EXCESSIVELY PRICED MEDICINES IN THE NETHERLANDS .85 -- 5.6 IMPLICATIONS DATA & MARKET EXCLUSIVITIES FOR COMPULSORY LICENSING 88 -- 5.7 INTERIM CONCLUSION .91 -- 6 COMPLEMENTARY MECHANISMS WITHIN AND BEYOND THE PATENT LAW CONTEXT 92 -- 6.1 CONSIDER SOCIALLY RESPONSIBLE LICENSING CONDITIONS FOR ACADEMIA 92 -- 6.2 STIMULATE VOLUNTARY LICENSING: PATENT POOLS AND CLEARINGHOUSES 93 -- 6.3 INCREASE COLLABORATION & COORDINATION WITH NATIONAL AND EUROPEAN COMPETITION AUTHORITIES IN THE PHARMACEUTICAL SECTOR AND IN PARTICULAR FOR EXCESSIVE PRICING .94 -- 6.4 INCREASE TRANSPARENCY ON DATA AND R&D COSTS 95 -- 6.5 IMPOSE CONDITIONS ON ACCESS & PRICING IN CASE OF PUBLIC FUNDING .95 -- 6.6 INCREASE COORDINATION ON PRICING & REIMBURSEMENT 95 -- 7 CONCLUSIONS 96 -- SUPPLEMENT .99 -- APPENDIX 1. COMPETITION CASES EXCESSIVE PRICING .99 -- APPENDIX 2. TABLE COMPARATIVE ANALYSIS CLS IN OTHER COUNTRIES 109 -- APPENDIX 3. INFORMATIVE CL CASES .111 -- APPENDIX 4. SUMMARY OF THE LEGAL FRAMEWORK FOR PHARMACY PREPARATIONS IN BELGIUM .112 -- APPENDIX 4.1. EUROPEAN AND BELGIAN LEGISLATION ON NON-INDUSTRIAL PREPARATIONS 113 -- APPENDIX 4.2. QUALITY RULES PREPARATIONS BY PHARMACIES IN BELGIUM 115 -- APPENDIX 4.3. DIFFERENT PRACTICES IN THE EUROPEAN UNION .116 -- APPENDIX 5. BRIEF OVERVIEW OF THE DRUGS PRICING CRITERIA IN BELGIUM 118
Part 2 – Economic study
LIST OF ABBREVIATIONS 3 -- 1 PROBLEM DESCRIPTION 4 -- 2 OBJECTIVES 5 -- 3 LITERATURE REVIEW METHODS 5 -- 3.1 UNDERSTANDING THE CONSEQUENCES OF COMPULSORY LICENSING 5 -- 3.2 COMBINING THEORY WITH PRACTICE 5 -- 3.3 APPLYING A FLEXIBLE AND PURPOSIVE SEARCH STRATEGY 6 -- 3.4 EXTRACTING AND SYNTHESISING DATA 6 -- 3.5 INTERACTING WITH THE STUDY COMMISSIONER 6 -- 4 LITERATURE REVIEW RESULTS 7 -- 4.1 SEARCH FLOW DIAGRAM . 7 -- 4.2 DATA EXTRACTION 8 -- 4.2.2 Empirical studies 19 -- 4.2.3 Remuneration .31 -- 5 EXAMINING THE ECONOMIC IMPACT OF CL FOR MEDICINES 33 -- 5.1 INDUSTRIAL CONSEQUENCES 34 -- 5.1.1 Development of a domestic pharmaceutical industry 34 -- 5.1.2 Reduced investment by originator pharmaceutical companies 37 -- 5.1.3 Reduced investment from other industries vulnerable to IP protection 39 -- 5.1.4 State retaliation .39 -- 5.2 HEALTH CONSEQUENCES .40 -- 5.2.1 Increased access for patients to expensive, innovative drugs .40 -- 5.2.2 Freeing of resources that can be invested elsewhere 41 -- 5.2.3 Reduced access to innovative drugs through fewer drug launches or fewer trials 41 -- 5.2.4 Reduced supply of innovative medicines due to lower investment in R&D 41 -- 5.3 ADEQUATE REMUNERATION FOR COMPULSORY LICENSES 42 -- 5.3.1 Adequate remuneration of CL in developing economies .43 -- 5.3.2 Adequate remuneration of CL in developed economies 44 -- 6 CONCLUSION .48 -- APPENDIX 1. SEARCH STRATEGY 58 -- APPENDIX 1.1. SEARCH STRATEGY IN GENERAL 58 -- APPENDIX 1.2. SEARCH STRATEGY FOR PEER-REVIEWED LITERATURE 59 -- APPENDIX 1.3. SEARCH STRATEGY FOR GREY LITERATURE .64
Part 3 – Overall conclusions
Link for e-copy: https://doi.org/10.57598/R356C Format of e-copy: PDF (2,29 MB) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=4841 Compulsory licensing for expensive medicines / Esther Van Zimmeren / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2022)
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