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Safety and efficacy of inhaled nitric oxide in the management of Hypoxemic respiratory failure in adults with acute respiratory distress syndrome / Gregory Duchscherer / Alberta [Canada] : Institute of Health Economics (2007)
Safety and efficacy of inhaled nitric oxide in the management of Hypoxemic respiratory failure in adults with acute respiratory distress syndrome [printed text] / Gregory Duchscherer, Author ; Bing Guo, Author . - Alberta [Canada] : Institute of Health Economics, 2007 . - x, 65 p. : ill. ; A5. - (IHE Report, ISSN 1710-6605) .
ISBN : 978-0-9780024-9-7 : 0 €
This report was prepared in collaboration with the Health Technology Assessment program of the Institute of Heath Economics, SEARCH Canada, and Calgary Health Region. It focuses on the published scientific evidence regarding the safety and efficacy of inhaled Nitric Oxide (iNO) in the management of hypoxemic respiratory failure in adult patients
with acute respiratory distress syndrome (ARDS). This report also includes local context data from the Calgary Health Region regarding outcomes from ARDS, and utilization of iNO therapy.
The purpose of this report is to examine the scientific evidence on the use of iNO in this population with the goal of producing new insights regarding the optimal use of this experimental therapy.
Languages : English (eng)
Descriptors: Classification
WF 600 Diseases of the Respiratory System - Lungs
Indexation
Canada ; Nitric Oxide ; Respiratory Distress Syndrome, Adult ; Respiratory Insufficiency ; Technology Assessment, Biomedical ; TherapyContents note: Acknowledgments i -- Competing Interest ii -- Executive Summary iv -- Glossary vi -- Abbreviations vii -- Table of Contents ix -- Introduction 1 -- Background 1 -- Definitions of Acute Lung Injury and ARDS 1 -- Incidence of ARDS 4 -- Etiology of ARDS 4 -- Pathology and Pathophysiology of ARDS 5 -- Prognosis of Patients with ARDS.6 -- Treatment of ARDS 7 -- Nitric Oxide 10 -- Nitric oxide chemical and biochemical interactions 10 -- Rationale for iNO therapy 11 -- Potential complications and safety concerns associated with iNO therapy 2 -- Cost of iNO therapy 13 -- Cost-effectiveness of iNO therapy 14 -- Regulatory Status 14 -- Local Context 15 -- Efficacy Of Inhaled Nitric Oxide In Ali/ards 18 -- Evidence from systematic reviews 18 -- Evidence from randomized controlled trials 21 -- Expert Opinion 27 -- Clinical Guidelines And Ongoing Clinical Trials 28 -- Discussion 29 -- Efficacy 29 -- Safety and Adverse Events 37 -- Cost of iNO therapy 38 -- Summary and Conclusion 38 -- Appendix A: Methodology 40 -- Appendix B: randomized controlled trials data extraction tables 47 -- References 57 -- Tables and Figures -- Figure 1 – ICU and hospital mortality with an ARDS diagnosis in the Calgary Health Region 16 -- Figure 2 – Total number of patients on iNO therapy per fiscal quarter in the Calgary Health Region 16 -- Figure 3 – Total iNO therapy usage per fiscal quarter in the Calgary Health Region 17 -- Figure 4 – Average Usage of iNO per patient in the Calgary Health Region 17 -- Figure 5 – Quarterly nitric oxide expenditure for the adult ICUs in the Calgary Health Region 18 -- Table 1 – Recommended criteria for ALI and ARDS 2 -- Table 2 – Components and individual values of the lung injury score 3 -- Table 3 – Etiology of ARDS 5 -- Table A.1 – Databases and search terms used in the search strategy 40 -- Table B.1 – Randomized Controlled Trials Data Extraction Table 47 Link for e-copy: http://www.ihe.ca/documents/IHE_Report_The_Use_of_Nitric_Oxide_in_Acute_Respirat [...] Format of e-copy: PDF (2,7 MB) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=1745 Copies(1)
Barcode Call number Media type Location Section Status 10273-01732 WF 600/DUC Book KCE Library (10.124) Not for loan Safety in Numbers / Suzanne Gordon / Cornell University Press (2008)
Safety in Numbers : Nurse-to-Patient Ratios and the Future of Health Care [printed text] / Suzanne Gordon, Author ; John Buchanan, Author ; Tanya Bretherton, Author . - Cornell University Press, 2008 . - 272 p. ; 24 cm.
ISBN : 978-0-8014-4683-2 : $ 30,95
Languages : English (eng)
Descriptors: Classification
W 76 Health manpower and services, distribution and characteristics
Indexation
Nursing ; Nursing Service, Hospital ; Nursing Staff ; Personnel ManagementAbstract: Legally mandated nurse-to-patient ratios are one of the most controversial topics in health care today. Ratio advocates believe that minimum staffing levels are essential for quality care, better working conditions, and higher rates of RN recruitment and retention that would alleviate the current global nursing shortage. Opponents claim that ratios will unfairly burden hospital budgets, while reducing management flexibility in addressing patient needs.
Safety in Numbers is the first book to examine the arguments for and against ratios. Utilizing survey data, interviews, and other original research, Suzanne Gordon, John Buchanan, and Tanya Bretherton weigh the cost, benefits, and effectiveness of ratios in California and the state of Victoria in Australia, the two places where RN staffing levels have been mandated the longest. They show how hospital cost cutting and layoffs in the 1990s created larger workloads and deteriorating conditions for both nurses and their patients—leading nursing organizations to embrace staffing level regulation. The authors provide an in-depth account of the difficult but ultimately successful campaigns waged by nurses and their allies to win mandated ratios. Safety in Numbers then reports on how nurses, hospital administrators, and health care policymakers handled ratio implementation.
With at least fourteen states in the United States and several other countries now considering staffing level regulation, this balanced assessment of the impact of ratios on patient outcomes and RN job performance and satisfaction could not be timelier. The authors' history and analysis of the nurse-to-patient ratios debate will be welcomed as an invaluable guide for patient advocates, nurses, health care managers, public officials, and anyone else concerned about the quality of patient care in the United States and the world.Contents note: Hospital restructuring and the erosion of nursing care in California and the United States -- Not out of thin air -- The hospital industry response -- Ratios redux -- Working life for nurses in the late 1990s in Australia : a snapshot -- How did it come to this? : the factors driving the intensification of nursing work -- Winning ratios in Victoria -- Evaluating the impact of ratios : an imperfect experiment -- What we know about nurse staffing -- Arguments against and alternatives to ratios. Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=4474 Hold
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Barcode Call number Media type Location Section Status 10273-03381 W76 / GOR Book KCE Library (10.124) Due for return by 11/24/2019 Readers who borrowed this document also borrowed:
The innovator's prescription Christensen, Clayton M. The nurse manager's guide to innovative staffing Mensik, Jennifer Arts in het ziekenhuis De Witte, Karel Emergency care and the public's health Pines, Jesse M. Gezondheidseconomie voor niet-economen Annemans, Lieven BADS Directory of Procedures The system of care handbook Stroul, Beth A. Goed ziek De Ridder, R. Learning for action Checkland, Peter De financiering van de ziekenhuizen Tuerlinckx, M. Capaciteitsplanning in de zorg Berden, Bart Safety of percutaneous aortic valve insertion / Hans Van Brabandt in BMC cardiovascular disorders, 9(2009)45 ([09/01/2009])
[article] Safety of percutaneous aortic valve insertion : A systematic review [printed text] / Hans Van Brabandt , Author ; Mattias Neyt , Author . - 2009 . - 7 p.
Languages : English (eng)
in BMC cardiovascular disorders > 9(2009)45 [09/01/2009] . - 7 p.
Descriptors: Classification
W 1 Serials. Periodicals
Indexation
Aged ; Aged, 80 and over ; Aortic Valve Stenosis ; Evidence-Based Medicine ; Great Britain ; Heart Catheterization ; Heart Valve Prosthesis Implantation ; Humans ; Journal Article ; Middle Aged ; Patient Selection ; Peer Review ; Review ; Risk Management ; Time Factors ; Treatment outcomeAbstract: BACKGROUND: The technique of percutaneous aortic valve implantation (PAVI) for the treatment of severe aortic stenosis (AS) has been introduced in 2002. Since then, many thousands such devices have worldwide been implanted in patients at high risk for conventional surgery. The procedure related mortality associated with PAVI as reported in published case series is substantial, although the intervention has never been formally compared with standard surgery. The objective of this study was to assess the safety of PAVI, and to compare it with published data reporting the risk associated with conventional aortic valve replacement in high-risk subjects.
METHODS: Studies published in peer reviewed journals and presented at international meetings were searched in major medical databases. Further data were obtained from dedicated websites and through contacts with manufacturers. The following data were extracted: patient characteristics, success rate of valve insertion, operative risk status, early and late all-cause mortality.
RESULTS: The first PAVI has been performed in 2002. Because of procedural complexity, the original transvenous approach from 2004 on has been replaced by the transarterial and transapical routes. Data originating from nearly 2700 non-transvenous PAVIs were identified. In order to reduce the impact of technical refinements and the procedural learning curve, procedure related safety data from series starting recruitment in April 2007 or later (n = 1975) were focused on. One-month mortality rates range from 6.4 to 7.4% in transfemoral (TF) and 11.6 to 18.6% in transapical (TA) series. Observational data from surgical series in patients with a comparable predicted operative risk, indicate mortality rates that are similar to those in TF PAVI but substantially lower than in TA PAVI. From all identified PAVI series, 6-month mortality rates, reflecting both procedural risk and mortality related to underlying co-morbidities, range from 10.0-25.0% in TF and 26.1-42.8% in TA series. It is not known what the survival of these patients would have been, had they been treated medically or by conventional surgery.
CONCLUSION: Safety issues and short-term survival represent a major drawback for the implementation of PAVI, especially for the TA approach. Results from an ongoing randomised controlled trial (RCT) should be awaited before further using this technique in routine clinical practice. In the meantime, both for safety concerns and for ethical reasons, patients should only be subjected to PAVI within the boundaries of such an RCT.Link for e-copy: http://www.biomedcentral.com/bmccardiovascdisord Format of e-copy: PDF [Open Access] Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=2358 [article]E-copies
Van Brabandt H_2009_BMC Cardiovasc Disord_9_45.pdfAdobe Acrobat PDF La santé en Belgique / Bruxelles [Belgium] : Ministère de l'intégration sociale, de la santé publique et de l'environnement (1993)
La santé en Belgique : Aperçu de la situation actuelle et tendances [printed text] . - Bruxelles [Belgium] : Ministère de l'intégration sociale, de la santé publique et de l'environnement, 1993 . - 117 p.
Languages : French (fre)
Descriptors: Classification
WA 900 Public health statistics (including narrative reports on health conditions and health surveys)
Indexation
Belgium ; Health SurveysRecord link: https://kce.docressources.info/index.php?lvl=notice_display&id=516 Hold
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Barcode Call number Media type Location Section Status 10273-00319 WA 900/SAN Report KCE Library (10.124) Available Santé et le bien-être des jeunes d'âge scolaire (la): Quoi de neuf depuis 1994? / Danielle Piette / Bruxelles : Université Libre de Bruxelles (ULB) (2003)
Santé et le bien-être des jeunes d'âge scolaire (la): Quoi de neuf depuis 1994? [printed text] / Danielle Piette, Author ; Laurence Kohn , Author ; Florence Parent, Author ; Yves Coppieters, Author ; Damien Favresse, Author ; Christine Bazelmans, Author ; Patrick de Smet, Author . - Bruxelles : Université Libre de Bruxelles (ULB), 2003.
ISSN : 331
Languages : French (fre)
Descriptors: Classification
WS - PEDIATRICSRecord link: https://kce.docressources.info/index.php?lvl=notice_display&id=132 Hold
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Barcode Call number Media type Location Section Status 10273-00331 WS 460/PIE Book KCE Library (10.124) Available La sante en chiffres, 1960-1983 / Paris : Organisation de Cooperation et de Developpement Economiques (1985)
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