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Bewaking van de vaccinveiligheid in België / Jo Robays / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2012)  

Bewaking van de vaccinveiligheid in België : plaats en beperkingen van een benadering gebaseerd op achtergrondincidenties [printed text] / Jo Robays, Author ; Germaine Hanquet, Author ; Dominique Roberfroid , Author ; Nancy Thiry, Author . - Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre, 2012 . - VII, 114 p. : Ill. ; A4. - (KCE Reports A. Health Services Research (HSR); 188A) . ISSN : D/2012/10.273/69 : € 0,00 Languages : English (eng) Dutch (nla) Descriptors: Indexation 2011-22 ; Adverse Drug Reaction Reporting Systems ; Pharmacovigilance ; Product Surveillance, Postmarketing ; R188 ; Vaccination Classification QW 805 Vaccines. Antitoxins. Toxoids Contents note: SYNTHESE 11 -- 1 INLEIDING 11 -- 1.1 VERSCHILLENDE BENADERINGEN VAN SIGNAALDETECTIE 12 -- 1.2 DOEL VAN DE STUDIE 12 -- 2 DATABASES DIE GEGEVENS OVER DE ACHTERGRONDINCIDENTIE IN BELGIË KUNNEN -- VERSTREKKEN 13 -- 2.1 GEGEVENSBRONNEN VAN DE OVERHEID 13 -- 2.1.1 Minimale Klinische Gegevens 13 -- 2.1.2 CARENET 13 -- 2.1.3 Overlijdensregister 14 -- 2.2 SENTINELNETWERKEN 14 -- 2.2.1 Netwerken voor huisartsen 14 -- 2.2.2 Pedisurv 15 -- 3 BEREKENING VAN DE ACHTERGRONDINCIDENTIE: EEN PILOTSTUDIE 15 -- 3.1 WIEGENDOOD 15 -- 3.2 SYNDROOM VAN GUILLAIN-BARRÉ 16 -- 3.3 STUIPEN 17 -- 3.4 HAALBAARHEID EN BETROUWBAARHEID VAN DE BEREKENING VAN DE -- ACHTERGRONDINCIDENTIE IN BELGIË 17 -- 4 UITDAGINGEN EN OPPORTUNITEITEN IN VERBAND MET DE BEWAKING VAN -- VACCINVEILIGHEID 18 -- 4.1 BEWAKING VAN DE VACCINVEILIGHEID IN BELGIË 18 -- 4.1.1 Gegevensvergaring 18 -- 4.1.2 Gegevensanalyse 20 -- 4.2 TEKORTKOMINGEN EN MOGELIJKE OPLOSSINGEN 20 -- 5 VOORUITGANG? 23 -- SCIENTIFIC REPORT 24 -- 1 BACKGROUND OF THE STUDY 24 -- 2 BACKGROUND RATES IN SAFETY SURVEILLANCE: OVERVIEW OF ISSUES 26 -- 2.1 USING BACKGROUND RATES FOR SIGNAL DETECTION. 26 -- 2.1.1 Computation 26 -- 2.1.2 Signal management: prioritization and evaluation 27 -- 2.2 CHALLENGES AND OPTIONS IN PHARMACOVIGILANCE BASED ON BACKGROUND RATES 28 -- 2.2.1 Counting events 28 -- 2.2.2 Counting exposed ones 31 -- 2.2.3 Confounding 32 -- 2.2.4 Analytical issues 33 -- 2.3 CHALLENGES AND OPPORTUNITIES FOR VACCINE SAFETY SURVEILLANCE BASED ON A -- BACKGROUND APPROACH 34 -- 3 BELGIAN DATABASES FOR COMPUTING BACKGROUND RATES 37 -- 3.1 INTRODUCTION & METHODS 37 -- 3.2 DESCRIPTION OF THE DATABASES 37 -- 3.2.1 Minimal Clinical Data 37 -- 3.2.2 Carenet 38 -- 3.2.3 GP sentinel practice networks 38 -- 3.2.4 Special Solidarity Fund 39 -- 3.2.5 Increased child allowance for disabled or ill children 39 -- 3.2.6 Pedisurv 39 -- 3.2.7 Cause-specific deaths 40 -- 3.2.8 The European Mortality Monitoring Project 40 -- 3.2.9 Vaccinnet 41 -- 3.2.10 Disease reporting at regional level 41 -- 3.3 CONCLUSION 42 -- BACKGROUND RATES IN EUROPE 42 -- 4.1 GENERAL INTRODUCTION 42 -- 4.2 METHODS 42 -- 4.3 POPULATION 43 -- 4.4 OUTCOMES 43 -- 5 ESTIMATION OF BACKGROUND RATES FOR SELECTED CONDITIONS IN BELGIUM 45 -- 5.1 SUDDEN INFANT DEATH 45 -- 5.1.1 Definitions 45 -- 5.1.2 Literature review 46 -- 5.1.3 Rates of SID in Belgium 50 -- 5.1.4 Conclusions on sudden infant deaths 53 -- 5.2 SUDDEN DEATH WITH UNKNOWN CAUSE IN ≥1 YEAR OF AGE 53 -- 5.2.1 Rationale 53 -- 5.2.2 Definitions 53 -- 5.2.3 Literature review 55 -- 5.2.4 Rates of sudden deaths in Belgium 56 -- 5.2.5 Conclusions on sudden deaths 60 -- 5.3 GUILLAIN-BARRÉ SYNDROME 60 -- 5.3.1 Rationale 60 -- 5.3.2 Definitions 60 -- 5.3.3 Literature review 60 -- 5.3.4 Background rates of Guillain-Barré Syndrome in the literature 61 -- 5.3.5 Seasonal or temporal patterns 63 -- 5.3.6 Prediction models 63 -- 5.3.7 Belgian data on GBS from Minimal Clinical Data 63 -- 5.3.8 Conclusions on Guillain-Barré syndrome (GBS) 65 -- 5.4 SEIZURES 66 -- 5.4.1 Case definition 66 -- 5.4.2 Literature review 66 -- 5.4.3 Results 67 -- 5.4.4 Belgian data 69 -- 5.4.5 Discussion 69 -- 6 POTENTIAL DETECTION OF CASES OF SD/SID, GBS, THROMBOCYTOPENIA AND -- CONVULSIONS FROM IMMUNOGLOBULIN’S PRESCRIPTIONS 69 -- 6.1 IMMUNOGLOBULINS FOR EXTRAVASCULAR ADMINISTRATION (J06BA01) 70 -- 6.2 IMMUNOGLOBULINS FOR INTRAVASCULAR ADMINISTRATION (J06BA02) 71 -- 7 MINIMAL CLINICAL DATA 72 -- 7.1 GUILLAIN-BARRÉ SYNDROME 72 -- 7.2 SEIZURES. 74 -- 7.3 DEMYELINATING DISEASE 75 -- 7.4 OPTIC NEURITIS 76 -- 7.5 BELL’S PALSY 77 -- 7.6 THROMBOCYTOPENIA 78 -- 7.7 GENERAL DISCUSSION ON MCD DATA 78 -- 8 PHARMACOVIGILANCE IN BELGIUM 79 -- 8.1 DATA COLLECTION 79 -- 8.2 DATA ANALYSIS 81 -- 9 GENERAL DISCUSSION AND RECOMMENDATIONS 82 -- APPENDICES. 83 -- REFERENCES 108 Link for e-copy: https://kce.fgov.be/sites/default/files/page_documents/188A_vaccinveiligheid_in_ [...] Format of e-copy: PDF (1,11 MB) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=3089

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Bewaking van de vaccinveiligheid in België / Jo Robays / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2012)  

Bewaking van de vaccinveiligheid in België : plaats en beperkingen van een benadering gebaseerd op achtergrondincidenties - SYNTHESE [printed text] / Jo Robays, Author ; Germaine Hanquet, Author ; Dominique Roberfroid , Author ; Nancy Thiry, Author . - Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre, 2012 . - 15 p. : Ill. ; A4. - (KCE Reports A. Health Services Research (HSR); 188As) . ISSN : D/2012/10273/72 : € 0,00 Languages : Dutch (nla) Descriptors: Indexation 2011-22 ; Adverse Drug Reaction Reporting Systems ; Pharmacovigilance ; Product Surveillance, Postmarketing ; R188 ; Vaccination Classification QW 805 Vaccines. Antitoxins. Toxoids Link for e-copy: https://kce.fgov.be/sites/default/files/page_documents/188A_vaccinveiligheid_in_ [...] Format of e-copy: PDF (336 KB) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=3090

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Cost-effectiveness of human papillomavirus vaccination in Belgium / Nancy Thiry in International Journal of Technology Assessment in Health Care, 25(2009)2 ([04/01/2009])  

[article] Cost-effectiveness of human papillomavirus vaccination in Belgium : do not forget about cervical cancer screening [printed text] / Nancy Thiry, Author ; Chris De Laet , Author ; Frank Hulstaert, Author ; Mattias Neyt , Author ; Huybrechts, Michel, Author ; Irina Cleemput , Author . - 2009 . - 161-170. Languages : English (eng) in International Journal of Technology Assessment in Health Care > 25(2009)2 [04/01/2009] . - 161-170 Descriptors: Classification W 1 Serials. Periodicals Indexation 2007-13 ; Adolescent ; Adult ; Belgium ; Child ; Cohort Studies ; Cost-Benefit Analysis ; Female ; Great Britain ; Health Care Costs ; Humans ; Journal Article ; Markov Chains ; Mass Screening ; Papillomavirus Vaccines ; Peer Review ; Quality-Adjusted Life Years ; R64 ; Uterine Cervical Neoplasms ; Vaccination Abstract: OBJECTIVES: The cost-effectiveness of adding a human papillomavirus (HPV) vaccination program in 12-year-old females to the recommended cervical cancer screening in Belgium is examined. Moreover, the health and economic consequences of a potential decline in screening uptake after initiation of a HPV vaccination program are investigated. METHODS: A static Markov model is developed to estimate the direct effect of vaccination on precancerous lesions and cervical cancers. RESULTS: Vaccination is estimated to avoid 20 percent of the cervical cancers occurring in a 12-year-old girls' cohort and to cost 32,665 euro per quality-adjusted life-year (QALY) gained (95 percent credibility interval [CrI]: 17,447 euro to 68,078 euro), assuming a booster injection after 10 years, a limited duration of protection and discounting costs and effects at 3 percent and 1.5 percent, respectively. Assuming lifelong protection, HPV vaccination is estimated to cost 14,382 euro (95 percent CrI: 9,238 euro to 25,644 euro) per QALY gained, while avoiding 50 percent of the cervical cancer cases. In the base-case, a 10 percent reduction in screening compliance after vaccination obliterates the effect of vaccination on cervical cancer cases avoided, whereas further declines in the level of screening compliance even turned out to be detrimental for the cohort's health, inducing a mean loss in QALYs and life-year gained compared with the situation prevaccination. CONCLUSIONS: An HPV vaccination program should only be considered if the level of screening after vaccination can be maintained. Link for e-copy: http://doi.org/10.1017/S0266462309090217 Format of e-copy: PDF [Requires Subscription] Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=2200 [article]

Couverture vaccinale du personnel des hôpitaux et maisons de repos et de soins contre le covid-19 / Nicolas Bouckaert / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2021)  

Couverture vaccinale du personnel des hôpitaux et maisons de repos et de soins contre le covid-19 : - une analyse cross-sectionnelle [printed text] / Nicolas Bouckaert, Author ; Stephan Devriese , Author ; Koen Van Den Heede , Author . - Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre, 2021 . - 18 p. : ill., ; A4. - (COVID-19 – KCE CONTRIBUTIONS, ISSN 2684-5830) . ISSN : D/2020/10.2733/27 : € 0,00 Languages : French (fre) Descriptors: Classification QW 806 Vaccination Indexation Belgium ; COVID-19 [Supplementary Concept] ; Health Workforce ; Vaccination Abstract: Ce rapport donne un aperçu de la couverture vaccinale dans tous les établissements de soins de santé belges (hôpitaux et MR/MRS), ainsi que des informations plus détaillées par type d'établissement, province et groupe d'âge. Cette analyse a été réalisée en collaboration avec l’ONSS, la Banque Carrefour de la Sécurité Sociale et la plateforme eHealth. Contents note: MESSAGES CLÉS 1 -- 1 INTRODUCTION 3 -- 1.1 Contexte 3 -- 1.2 Questions de recherche et portée de l’étude 3 -- 2 MÉTHODE 4 -- 2.1 Sources de données 4 -- 2.2 Couplage 5 -- 2.3 Analyse 5 -- 3 RÉSULTATS 7 -- 3.1 Couverture vaccinale dans les établissements de soins 7 -- 3.2 Variation de la couverture vaccinale en fonction de la taille des établissements de soins 9 -- 3.3 Variation de la couverture vaccinale en fonction de l’âge 11 -- 3.4 Qui est vacciné et qui ne l’est pas ? 13 Link for e-copy: https://kce.fgov.be/sites/default/files/atoms/files/COVID-19_Contribution_2021-6 [...] Format of e-copy: PDF (2,2 Mb) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=4763

Economic evaluation of vaccination programmes in human / Philippe Beutels / Antwerpen [Belgium] : Universiteit Antwerpen (UA) (2002)

Economic evaluation of vaccination programmes in human = Economische evaluatie van vaccinatieprogramma's bij mensen : A methodological exploration with applications to hepatitis B, varicella-zoster, measles, pertussis, hepatitis A and pneumococcal vaccination [printed text] / Philippe Beutels, Author ; A. Meheus, Thesis advisor . - Antwerpen [Belgium] : Universiteit Antwerpen (UA), 2002 . - xvi, 523 p. : ill. ; 25 cm.. - (Faculteit Geneeskunde. Vakgroep Epidemiologie en Sociale Geneeskunde) . ISBN : 90-901552-8-7 PhD dissertation Languages : English (eng) Descriptors: Classification QW 806 Vaccination Indexation Academic Dissertations ; Humans ; Program Evaluation ; Vaccination Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=868

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Methods for Health Economic Evaluation of Vaccines and Immunization Decision Frameworks / B. Ultsch in Pharmacoeconomics, 34(2016)03 ([03/01/2016])  

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New models for the evaluation of cervical cancer vaccination: challenges and new opportunities / GalxoSmithKline = GSK (2007)

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Rapid review of the evidence on a covid-19 booster dose after a primary vaccination schedule / Vicky Jespers / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2021)  

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Surveillance de la sécurité vaccinale en Belgique / Jo Robays / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2012)  

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Surveillance de la sécurité vaccinale en Belgique / Jo Robays / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2012)  

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Vaccinatiegraad tegen COVID-19 van het personeel in Ziekenhuizen en Woonzorgcentra / Nicolas Bouckaert / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2021)  

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[Vaccine safety surveillance in Belgium : place and limits of a background rate approach] / Jo Robays / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2012)  

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