Author details
Author Leen Verleye
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Available item(s) by this author (69)
Add the result to your basket Make a suggestion Refine your search Apply to external sourcesActualisation des recommandations cliniques pour le cancer de l’oesophage et de l’estomac / T. Lerut / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2012)
ISSN : D/2012/10.273/33 : € 0,00
Languages : English (eng) French (fre)
Descriptors: Indexation
2009-02 ; Esophageal Neoplasms ; Practice Guideline [Publication type] ; R179 ; Stomach Neoplasms
Classification
WI 149 Digestive System -- NeoplasmsAbstract: Le Centre Fédéral d’Expertise des Soins de Santé (KCE) et le Collège d’Oncologie ont réalisé une mise à jour des recommandations de bonne pratique pour la prise en charge des cancers de l’œsophage et de l’estomac, qui dataient de 2008. Il existe à présent davantage de preuves pour recommander la combinaison chimio-radiothérapie (cancer de l’œsophage) et la chimiothérapie (cancer de l’estomac) avant une intervention chirurgicale. De plus, le diagnostic et le traitement seront de préférence assurés par des prestataires de soins bénéficiant d’une expérience suffisante et qui se concertent à chaque stade de la prise en charge lors de réunions multidisciplinaires. Contents note: 1. INTRODUCTION 7 -- 1.1. SCOPE 7 -- 1.2. EPIDEMIOLOGY 7 -- 1.2.1. Oesophageal cancer 7 -- 1.2.2. Gastric cancer 9 -- 2. METHODOLOGY 10 -- 2.1. GENERAL APPROACH 10 -- 2.2. CLINICAL QUESTIONS 10 -- 2.3. LITERATURE SEARCH AND SELECTION CRITERIA 10 -- 2.4. QUALITY APPRAISAL 10 -- 2.5. DATA EXTRACTION AND EVIDENCE SUMMARY 10 -- 2.6. FORMULATION OF RECOMMENDATIONS 12 -- 3. DEFINITIONS 13 -- 3.1. TOPOGRAPHIC DEFINITIONS 13 -- 3.2. EARLY LESIONS 14 -- 3.2.1. Histology of the normal oesophagus 14 -- 3.2.2. Barrett’s oesophagus 15 -- 3.2.3. Dysplasia in squamous epithelium 16 -- 3.2.4. Dysplasia in columnar epithelium 16 -- 3.3. EARLY VERSUS LOCALLY-ADVANCED INVASIVE DISEASE 19 -- 4. CLINICAL RECOMMENDATIONS FOR OESOPHAGEAL CANCER 19 -- 4.1. FLOWCHART 19 -- 4.2. STAGING 20 -- 4.2.1. Computed tomography 20 -- 4.2.2. Endoscopic ultrasonography 21 -- 4.2.3. Positron-emission tomography 22 -- 4.2.4. Magnetic resonance imaging 23 -- 4.2.5. Bronchoscopy and bronchoscopic ultrasound 23 -- 4.2.6. Thoracoscopy and laparoscopy 23 -- 4.3. TREATMENT OF MUCOSAL CANCER 25 -- 4.4. TREATMENT OF CANCER BEYOND THE MUCOSA 26 -- 4.4.1. Neoadjuvant treatment 26 -- 4.4.2. Response assessment and restaging 30 -- 4.4.3. Surgical treatment 32 -- 4.4.4. Adjuvant treatment 36 -- 4.4.5. Non-surgical treatment with curative intent 37 -- 4.5. TREATMENT OF METASTATIC DISEASE 39 -- 4.5.1. Endoscopic ablation 40 -- 4.5.2. Stents 40 -- 4.5.3. Palliative surgery 41 -- 4.5.4. Systemic treatment 41 -- 4.5.5. Radiotherapy 41 -- 4.6. SUPPORTIVE CARE 43 -- 4.7. FOLLOW-UP 43 -- 4.8. TREATMENT OF RECURRENT DISEASE 44 -- 5. CLINICAL RECOMMENDATIONS FOR GASTRIC CANCER 45 -- 5.1. FLOWCHART 45 -- 5.2. STAGING 46 -- 5.2.1. Computed tomography 46 -- 5.2.2. Endoscopic ultrasonography 48 -- 5.2.3. Positron-emission tomography 49 -- 5.2.4. Magnetic resonance imaging 50 -- 5.2.5. Laparoscopy 50 -- 5.2.6. Sentinel lymph node mapping 51 -- 5.3. TREATMENT OF MUCOSAL CANCER 52 -- 5.4. TREATMENT OF CANCER BEYOND THE MUCOSA 53 -- 5.4.1. Neoadjuvant treatment 53 -- 5.4.2. Surgical treatment 55 -- 5.4.3. Adjuvant treatment 59 -- 5.5. TREATMENT OF METASTATIC DISEASE 61 -- 5.5.1. Palliative surgery 61 -- 5.5.2. Stents 61 -- 5.5.3. Chemotherapy and targeted treatment 62 -- 5.5.4. Supportive care 63 -- 5.6. FOLLOW-UP 64 -- 5.7. TREATMENT OF RECURRENT DISEASE 65 -- 6. REFERENCES 66 Link for e-copy: https://doi.org/10.57598/R179B Format of e-copy: PDF (1,1 MB) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=2996 Copies
Barcode Call number Media type Location Section Status No copy Are systemic antibiotics indicated in children presenting with an odontogenic abscess in the primary dentition? / Roos Leroy in Clinical oral investigations, 25(2021)05 ([05/01/2021])
Languages : English (eng)
in Clinical oral investigations > 25(2021)05 [05/01/2021] . - 8 pp.
Descriptors: Classification
W 1 Serials. Periodicals
Indexation
Abscess ; Antibiotic Prophylaxis ; Journal Article ; Peer Review ; R332 ; ReviewAbstract: Objectives: This systematic review aimed to assess (1) whether systemic antibiotics are beneficial or harmful in healthy children who present with an odontogenic abscess in the primary dentition with or without systemic involvement and (2) if antibiotics are beneficial, which type, dosage and duration are the most effective.
Materials and methods: Electronic databases (Medline, Embase, and the Cochrane Library) were screened from 1948 up to August 2020. No filters with respect to study design were applied. Outcomes of interest included pain, swelling, pain relief, adverse effects, signs of infection, quality-of-life measurements and medication required for pain relief.
Results: Altogether, 352 titles and abstracts were screened for eligibility; of these, 19 were selected for full text assessment. All were excluded because none of them fulfilled the inclusion criteria and addressed the (adjunctive) use of antibiotics in children who present with an odontogenic abscess in the primary dentition.
Conclusions: At present, there is no single randomised or non-randomised clinical study evaluating the effectiveness and harms of systemic antibiotics administered in children who present with an odontogenic abscess in the primary dentition.
Clinical relevance: There is no clinical evidence to support nor to refute the use of antibiotics in children who present with an odontogenic abscess in the primary dentition without signs of local spread or systemic involvement. Given this lack of scientific evidence, the use of antibiotics cannot be recommended in these children. Well-designed clinical trials are indicated to fully understand the impact and necessity of antibiotics in these situations.Link for e-copy: https://doi.org/10.1007/s00784-021-03862-3 Format of e-copy: PDF [Requires Subscription] Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=4776 [article]
ISSN : D/2021/10.273/23 : € 0,00
Languages : English (eng)
Descriptors: Indexation
2018-02 ; Antineoplastic Agents ; Neoplasms ; R343 ; Randomized Controlled Trials ; Review ; Technology Assessment, Biomedical
Classification
QV 269 Antineoplastic agents. Antineoplastic antibioticsContents note: SCIENTIFIC REPORT 22 -- 1 INTRODUCTION 22 -- 1.1 SETTING THE SCENE 22 -- 1.1.1 Increasing expenditures for oncology drugs 22 -- 1.1.2 The increasing cancer drug prices 23 -- 1.1.3 Patient benefit, no longer a hard requirement for marketing authorisation 24 -- 1.2 ARE THE EXTRA EXPENDITURES ASSOCIATED WITH PATIENT BENEFITS? 26 -- 1.2.1 Cancer drugs as one of many contributors to cancer survival 26 -- 1.2.2 Small and uncertain patient benefit of new cancer medicines 27 -- 2 OBJECTIVES 28 -- 2.1 OPPORTUNITY COST OR DISPLACEMENT EFFECT 28 -- 2.2 RESEARCH QUESTIONS 28 -- 3 METHODOLOGY 29 -- 3.1 PART 1: DATABASES, STATISTICAL ANALYSES, AND PRESENTATION OF RESULTS 29 -- 3.1.1 Belgian Cancer Registry (BCR) data selection and linkage with Intermutualistic Agency (IMA) data and vital status 29 -- 3.1.1.1 Selection of the study population in the Belgian Cancer Registry database 29 -- 3.1.1.2 Linkage with health insurance data 32 -- 3.1.1.3 Vital status 32 -- 3.1.2 Statistical analyses 33 -- 3.1.2.1 Descriptive analyses 33 -- 3.1.2.2 Survival analysis 33 -- 3.1.2.3 Statistical software 34 -- 3.1.3 Graphics and Tables 34 -- 3.2 PART 2: SELECTION OF DRUGS 35 -- 3.2.1 Selection criteria and process 35 -- 3.2.2 Selected cancer types and drugs 37 -- 3.3 PART 3: LITERATURE SEARCHES 37 -- 3.3.1 Search medical literature 37 -- 3.3.2 Search economic literature 38 -- 3.4 PART 4: RIZIV REIMBURSEMENT CRITERIA 39 -- 4 RESULTS PER CANCER TYPE 40 -- 4.1 BREAST CANCER 40 -- 4.1.1 Introduction 40 -- 4.1.2 Observational data 42 -- 4.1.2.1 Patient characteristics, survival and expenditures 42 -- 4.1.2.2 Drug uptake for a selection of drugs during the first 5 years after diagnosis 47 -- 4.1.3 Medical literature: efficacy 48 -- 4.1.3.1 HER2(+) Breast cancer: neo-adjuvant and adjuvant setting (pertuzumab) 48 -- 4.1.3.2 HER2(+) Breast cancer: metastatic disease or locally advanced disease – first line (pertuzumab) 49 -- 4.1.3.3 HER2(+) Breast cancer: metastatic disease or locally advanced disease – second line (pertuzumab, trastuzumab emtansine) 49 -- 4.1.3.4 HER2(-) Breast cancer: metastatic disease or locally advanced disease 50 -- 4.1.3.5 Discussion 50 -- 4.1.4 Economic literature: cost-effectiveness 51 -- 4.1.5 Summary 57 -- 4.2 CHRONIC MYELOID LEUKAEMIA 59 -- 4.2.1 Introduction 59 -- 4.2.2 Observational data 60 -- 4.2.2.1 Patient characteristics, survival and expenditures 60 -- 4.2.2.2 Drug uptake for a selection of drugs during the first 5 years after diagnosis 67 -- 4.2.3 Medical literature: efficacy 67 -- 4.2.3.1 First-line treatment 68 -- 4.2.3.2 Second- and third-line treatment 70 -- 4.2.3.3 Discussion 70 -- 4.2.4 Economic literature: cost-effectiveness 71 -- 4.2.5 Summary 76 -- 4.3 COLORECTAL CANCER 78 -- 4.3.1 Introduction 78 -- 4.3.2 Observational data 79 -- 4.3.2.1 Patient characteristics, survival and expenditures 79 -- 4.3.2.2 Drug uptake for a selection of drugs during the first 5 years after diagnosis 84 -- 4.3.3 Medical literature: efficacy 84 -- 4.3.3.1 First-line treatment 85 -- 4.3.3.2 Second-line (or later) treatment 86 -- 4.3.3.3 Discussion 87 -- 4.3.4 Economic literature: cost-effectiveness 87 -- 4.3.5 Summary 91 -- 4.4 HEAD AND NECK CANCER 93 -- 4.4.1 Introduction 93 -- 4.4.2 Observational data 94 -- 4.4.2.1 Patient characteristics, survival and expenditures 94 -- 4.4.2.2 Drug uptake for a selection of drugs during the first 5 years after diagnosis 100 -- 4.4.3 Medical literature: efficacy 100 -- 4.4.3.1 Discussion 102 -- 4.4.4 Economic literature: cost-effectiveness 103 -- 4.4.5 Summary 106 -- 4.5 MELANOMA 107 -- 4.5.1 Introduction 107 -- 4.5.2 Observational data 108 -- 4.5.2.1 Patient characteristics, survival and expenditures 108 -- 4.5.2.2 Drug uptake for a selection of drugs during the first 5 years after diagnosis 119 -- 4.5.3 Medical literature: efficacy 120 -- 4.5.3.1 BRAF and MEK inhibitors melanoma 121 -- 4.5.3.2 Immunotherapy in melanoma 122 -- 4.5.3.3 Discussion 123 -- 4.5.4 Economic literature: cost-effectiveness 124 -- 4.5.5 Summary 129 -- 4.6 MESOTHELIOMA 132 -- 4.6.1 Introduction 132 -- 4.6.2 Observational data 132 -- 4.6.2.1 Patient characteristics, survival and expenditures 132 -- 4.6.2.2 Drug uptake for a selection of drugs during the first 5 years after diagnosis 139 -- 4.6.3 Medical literature: efficacy 139 -- 4.6.3.1 Discussion 140 -- 4.6.4 Economic literature: cost-effectiveness 141 -- 4.6.5 Summary 142 -- 4.7 MULTIPLE MYELOMA 143 -- 4.7.1 Introduction 143 -- 4.7.2 Observational data 145 -- 4.7.2.1 Patient characteristics, survival and expenditures 145 -- 4.7.2.2 Drug uptake for a selection of drugs during the first 5 years after diagnosis 150 -- 4.7.3 Medical literature: efficacy 150 -- 4.7.3.1 Multiple Myeloma: First-line treatment in adult patients ineligible for stem-cell -- transplantation 151 -- 4.7.3.2 Multiple myeloma: first-line treatment in adult patients eligible for stem-cell -- transplant 152 -- 4.7.3.3 Multiple myeloma: treatment of relapsed or refractory disease 152 -- 4.7.3.4 Discussion 153 -- 4.7.4 Economic literature: cost-effectiveness 154 -- 4.7.5 Summary 158 -- 4.8 NON-HODGKIN LYMPHOMA 160 -- 4.8.1 Introduction 160 -- 4.8.2 Observational data 161 -- 4.8.2.1 Patient characteristics, survival and expenditures 161 -- 4.8.2.2 Drug uptake for a selection of drugs during the first 5 years after diagnosis 175 -- 4.8.3 Medical literature: efficacy 176 -- 4.8.3.1 CLL/SLL 176 -- 4.8.3.2 DLBCL 178 -- 4.8.3.3 Mantle cell lymphoma 179 -- 4.8.3.4 Discussion 181 -- 4.8.4 Economic literature: cost-effectiveness 183 -- 4.8.4.1 Chronic lymphocytic leukaemia 183 -- 4.8.4.2 Mantel-cell lymphoma 188 -- 4.8.5 Summary 190 -- 4.8.5.1 CLL/SLL 190 -- 4.8.5.2 DLBCL 191 -- 4.8.5.3 Mantle cell lymphoma 192 -- 4.9 NON-SMALL CELL LUNG CANCER 193 -- 4.9.1 Introduction 193 -- 4.9.2 Observational data 194 -- 4.9.2.1 Patient characteristics, survival and expenditures 194 -- 4.9.2.2 Drug uptake for a selection of drugs during the first 5 years after diagnosis 199 -- 4.9.3 Medical literature: efficacy 199 -- 4.9.3.1 Anti-EGFR therapy in NSCLC 200 -- 4.9.3.2 ALK inhibitors for non-small cell lung cancer 203 -- 4.9.3.3 Immunotherapy 203 -- 4.9.3.4 Discussion 205 -- 4.9.4 Economic literature: cost-effectiveness 205 -- 4.9.5 Summary 209 -- 4.10 OVARIAN CANCER 211 -- 4.10.1 Introduction 211 -- 4.10.2 Observational data 211 -- 4.10.2.1 Patient characteristics, survival and expenditures 211 -- 4.10.2.2 Drug uptake for a selection of drugs during the first 5 years after diagnosis 220 -- 4.10.3 Medical literature: efficacy 220 -- 4.10.3.1 Bevacizumab in ovarian cancer 221 -- 4.10.3.2 Discussion 222 -- 4.10.4 Economic literature: cost-effectiveness 222 -- 4.10.5 Summary 226 -- 4.11 PROSTATE CANCER 227 -- 4.11.1 Introduction 227 -- 4.11.2 Observational data 227 -- 4.11.2.1 Patient characteristics, survival and expenditures 227 -- 4.11.2.2 Drug uptake for a selection of drugs during the first 5 years after diagnosis 233 -- 4.11.3 Medical literature: efficacy 233 -- 4.11.3.1 Discussion 235 -- 4.11.4 Economic literature: cost-effectiveness 235 -- 4.11.5 Summary 238 -- 4.12 RENAL CELL CARCINOMA (RCC) 239 -- 4.12.1 Introduction 239 -- 4.12.2 Observational data 241 -- 4.12.2.1 Patient characteristics, survival and expenditures 241 -- 4.12.2.2 Drug uptake for a selection of drugs during the first 5 years after diagnosis 247 -- 4.12.3 Medical literature: efficacy 249 -- 4.12.3.1 Targeted therapy – first line treatment 250 -- 4.12.3.2 Targeted therapy – second line treatment 250 -- 4.12.3.3 Immunotherapy 251 -- 4.12.3.4 Discussion 252 -- 4.12.4 Economic literature: cost-effectiveness 253 -- 4.12.5 Summary 259 -- 5 USE OF ANTICANCER DRUGS AT THE END OF LIFE 261 -- 6 SUMMARY 266 -- 7 DISCUSSION 276 -- 7.1 REAL-WORLD OBSERVATIONAL DATA 276 -- 7.1.1 Data from the Belgian Cancer Registry (BCR) and Intermutualistic Agency (IMA) – strengths/limitations and nuance needed 276 -- 7.1.2 Limitations inherent to the use of observational data – no good estimate of treatment effect 280 -- 7.2 LIMITED BENEFITS IN OVERALL SURVIVAL 284 -- 7.3 QOL AS AN IMPORTANT ENDPOINT 287 -- 7.3.1 A patient-relevant endpoint in clinical trials 287 -- 7.3.2 Measuring QoL with a generic utility instrument 287 -- 7.3.3 Improvement needed in measuring and reporting QoL, and using the results in economic evaluations 288 -- 7.3.4 An example to show (the importance of) transparent reporting of QoL data 292 -- 7.4 THE USE OF PROGRESSION-FREE SURVIVAL AS A SURROGATE ENDPOINT 295 -- 7.4.1 Is PFS a valid surrogate for OS?. 295 -- 7.4.2 Can PFS be considered as a surrogate for quality of life? 296 -- 7.4.3 The problem of PFS in economic evaluations 297 -- 7.4.4 Do we try hard enough? Searching for a solution that fits both goals 298 -- 7.5 SUBSTANTIAL INCREASE IN GROSS EXPENDITURES, LIMITED BY REFUNDS AND TAXES 299 -- 7.5.1 Managed entry agreement refunds 299 -- 7.5.2 Taxes and clawback 300 -- 7.6 MANAGED ENTRY AGREEMENT 301 -- 7.6.1 Managed entry agreement – when the exception becomes the rule 301 -- 7.6.2 Incentives to demonstrate survival or QoL benefits for the patients 302 -- 7.6.2.1 Before marketing approval 302 -- 7.6.2.2 After marketing approval 304 -- 7.6.3 Confidential prices 307 -- 7.6.3.1 A short-term advantage creating long-term problems and making the system intransparent 307 -- 7.6.3.2 Confidential prices making economic evaluations and policy decisions intransparent 308 -- 7.7 WHY WE MAINLY RELIED ON UK DOSSIERS FOR INFORMATION ON ECONOMIC EVALUATIONS IN THIS REPORT 309 -- 7.8 THE IMPORTANCE OF THE (DISCOUNT FOR THE) COMPARATOR 311 -- 7.9 DIFFERENT ARGUMENTS USED FROM DIFFERENT PERSPECTIVES 313 -- REFERENCES 317 Link for e-copy: https://doi.org/10.57598/R343C Format of e-copy: PDF (11 Mb) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=4747
ISSN : D/2021/10.273/24 : € 0,00
Languages : English (eng)
Descriptors: Indexation
2018-02 ; Antineoplastic Agents ; Neoplasms ; R343 ; Randomized Controlled Trials ; Review ; Technology Assessment, Biomedical
Classification
QV 269 Antineoplastic agents. Antineoplastic antibioticsContents note: APPENDIX 1. BREAST CANCER 56 -- APPENDIX 1.1. BCR DATA 56 -- Appendix 1.1.1. Descriptive statistics 56 -- Appendix 1.1.2. Uptake of selected drugs 92 -- APPENDIX 1.2. REIMBURSEMENT CRITERIA FOR SELECTED DRUGS 94 -- APPENDIX 1.3. MEDICAL LITERATURE: SEARCH FOR EVIDENCE 100 -- Appendix 1.3.1. Search medical literature (systematic reviews) 100 -- Appendix 1.3.2. Critical appraisal systematic reviews 104 -- Appendix 1.3.3. Search strategy 107 -- APPENDIX 1.4. ECONOMIC LITERATURE 118 -- Appendix 1.4.1. Search economic literature (HTA reports) 118 -- Appendix 1.4.2. Results economic literature (HTA reports) 121 -- APPENDIX 2. CHRONIC MYELOID LEUKAEMIA 147 -- APPENDIX 2.1. BCR DATA 147 -- Appendix 2.1.1. Descriptive statistics 147 -- Appendix 2.1.2. Uptake of selected drugs 166 -- APPENDIX 2.2. REIMBURSEMENT CRITERIA FOR SELECTED DRUGS 167 -- APPENDIX 2.3. MEDICAL LITERATURE: SEARCH FOR EVIDENCE 173 -- Appendix 2.3.1. Search medical literature (systematic reviews) 173 -- Appendix 2.3.2. Critical appraisal systematic reviews 177 -- Appendix 2.3.3. Search strategy 180 -- APPENDIX 2.4. ECONOMIC LITERATURE 189 -- Appendix 2.4.1. Search economic literature (HTA reports) 189 -- Appendix 2.4.2. Results economic literature (HTA reports) 192 -- APPENDIX 3. COLORECTAL CANCER 207 -- APPENDIX 3.1. BCR DATA 207 -- Appendix 3.1.1. Descriptive statistics 207 -- Appendix 3.1.2. Uptake of selected drugs 244 -- APPENDIX 3.2. REIMBURSEMENT CRITERIA FOR SELECTED DRUGS 246 -- APPENDIX 3.3. MEDICAL LITERATURE: SEARCH FOR EVIDENCE 249 -- Appendix 3.3.1. Search medical literature (systematic reviews) 249 -- Appendix 3.3.2. Critical appraisal systematic reviews 256 -- Appendix 3.3.3. Search strategy 258 -- APPENDIX 3.4. ECONOMIC LITERATURE 274 -- Appendix 3.4.1. Search economic literature (HTA reports) 274 -- Appendix 3.4.2. Results economic literature (HTA reports) 276 -- APPENDIX 4. HEAD & NECK CANCER 290 -- APPENDIX 4.1. BCR DATA 290 -- Appendix 4.1.1. Descriptive statistics 290 -- Appendix 4.1.2. Uptake of selected drug 341 -- APPENDIX 4.2. REIMBURSEMENT CRITERIA FOR SELECTED DRUGS 342 -- APPENDIX 4.3. MEDICAL LITERATURE: SEARCH FOR EVIDENCE 343 -- Appendix 4.3.1. Search medical literature (systematic reviews) 343 -- Appendix 4.3.2. Critical appraisal systematic reviews 346 -- Appendix 4.3.3. Search strategy 347 -- APPENDIX 4.4. ECONOMIC LITERATURE 350 -- Appendix 4.4.1. Search economic literature (HTA reports) 350 -- Appendix 4.4.2. Results economic literature (HTA reports) 352 -- APPENDIX 5. MELANOMA 358 -- APPENDIX 5.1. BCR DATA 358 -- Appendix 5.1.1. Descriptive statistics 358 -- APPENDIX 5.2. REIMBURSEMENT CRITERIA FOR SELECTED DRUGS 419 -- APPENDIX 5.3. MEDICAL LITERATURE: SEARCH FOR EVIDENCE 421 -- Appendix 5.3.1. Search medical literature (systematic reviews) 421 -- Appendix 5.3.2. Melanoma: Critical appraisal systematic reviews. 426 -- Appendix 5.3.3. Search strategy 428 -- APPENDIX 5.4. ECONOMIC LITERATURE 438 -- Appendix 5.4.1. Search economic literature (HTA reports) 438 -- Appendix 5.4.2. Results economic literature (HTA reports) 441 -- APPENDIX 6. MESOTHELIOMA 471 -- APPENDIX 6.1. BCR DATA 471 -- Appendix 6.1.1. Descriptive statistics 471 -- Appendix 6.1.2. Descriptive statistics 498 -- Appendix 6.1.3. Uptake of selected drugs 525 -- APPENDIX 6.2. REIMBURSEMENT CRITERIA FOR SELECTED DRUGS 525 -- APPENDIX 6.3. MEDICAL LITERATURE: SEARCH FOR EVIDENCE 525 -- Appendix 6.3.1. Search medical literature (systematic reviews) 525 -- Appendix 6.3.2. Critical appraisal systematic reviews 527 -- Appendix 6.3.3. Search strategy 528 -- APPENDIX 6.4. ECONOMIC LITERATURE 533 -- Appendix 6.4.1. Search economic literature (HTA reports) 533 -- Appendix 6.4.2. Results economic literature (HTA reports) 534 -- APPENDIX 7. MULTIPLE MYELOMA 538 -- APPENDIX 7.1. BCR DATA 538 -- Appendix 7.1.1. Descriptive statistics 538 -- Appendix 7.1.2. Uptake of selected drugs 545 -- APPENDIX 7.2. REIMBURSEMENT CRITERIA FOR SELECTED DRUGS 546 -- APPENDIX 7.3. MEDICAL LITERATURE: SEARCH FOR EVIDENCE 549 -- Appendix 7.3.1. Search medical literature (systematic reviews) 549 -- Appendix 7.3.2. Critical appraisal systematic reviews 553 -- Appendix 7.3.3. Search strategy 556 -- APPENDIX 7.4. ECONOMIC LITERATURE 562 -- Appendix 7.4.1. Search economic literature (HTA reports) 562 -- Appendix 7.4.2. Results economic literature (HTA reports) 565 -- APPENDIX 8. NON HODGKIN 587 -- APPENDIX 8.1. BCR DATA 587 -- Appendix 8.1.1. Descriptive statistics 587 -- Appendix 8.1.2. Uptake of selected drugs 611 -- APPENDIX 8.2. REIMBURSEMENT CRITERIA FOR SELECTED DRUGS 612 -- APPENDIX 8.3. MEDICAL LITERATURE: SEARCH FOR EVIDENCE 614 -- Appendix 8.3.1. Search medical literature (systematic reviews) 614 -- Appendix 8.3.2. Critical appraisal systematic reviews 620 -- Appendix 8.3.3. Search strategy 628 -- APPENDIX 8.4. ECONOMIC LITERATURE 664 -- Appendix 8.4.1. Search economic literature (HTA reports) 664 -- Appendix 8.4.2. Results economic literature (HTA reports) 667 -- Appendix 8.4.3. Mantel-cell lymphoma 681 -- APPENDIX 9. NON-SMALL CELL LUNG CANCER 684 -- APPENDIX 9.1. BCR DATA 684 -- Appendix 9.1.1. Descriptive statistics 684 -- Appendix 9.1.2. Uptake of selected drugs 720 -- APPENDIX 9.2. REIMBURSEMENT CRITERIA FOR SELECTED DRUGS 721 -- APPENDIX 9.3. MEDICAL LITERATURE: SEARCH FOR EVIDENCE 724 -- Appendix 9.3.1. Search medical literature (systematic reviews) 724 -- Appendix 9.3.2. Critical appraisal systematic reviews 732 -- Appendix 9.3.3. Search strategy 736 -- APPENDIX 9.4. ECONOMIC LITERATURE 747 -- Appendix 9.4.1. Search economic literature (HTA reports) 747 -- Appendix 9.4.2. Results economic literature (HTA reports) 751 -- APPENDIX 10. OVARIAN CANCER 786 -- APPENDIX 10.1. BCR DATA 786 -- Appendix 10.1.1. Descriptive statistics 786 -- Appendix 10.1.2. Uptake of selected drugs 873 -- APPENDIX 10.2. REIMBURSEMENT CRITERIA FOR SELECTED DRUGS 874 -- APPENDIX 10.3. MEDICAL LITERATURE: SEARCH FOR EVIDENCE 876 -- Appendix 10.3.1. Search medical literature (systematic reviews) 876 -- Appendix 10.3.2. Critical appraisal systematic reviews 878 -- Appendix 10.3.3. Search strategy 880 -- APPENDIX 10.4. ECONOMIC LITERATURE 887 -- Appendix 10.4.1. Search economic literature (HTA reports) 887 -- Appendix 10.4.2. Results economic literature (HTA reports) 889 -- APPENDIX 11. PROSTATE CANCER 898 -- APPENDIX 11.1. BCR DATA 898 -- Appendix 11.1.1. Descriptive statistics 898 -- Appendix 11.1.2. Uptake of selected drugs 951 -- APPENDIX 11.2. REIMBURSEMENT CRITERIA FOR SELECTED DRUGS 951 -- APPENDIX 11.3. MEDICAL LITERATURE: SEARCH FOR EVIDENCE 952 -- Appendix 11.3.1. Search medical literature (systematic reviews) 952 -- Appendix 11.3.2. Critical appraisal systematic reviews 956 -- Appendix 11.3.3. Search strategy 958 -- APPENDIX 11.4. ECONOMIC LITERATURE 965 -- Appendix 11.4.1. Search economic literature (HTA reports) 965 -- Appendix 11.4.2. Results economic literature (HTA reports) 967 -- APPENDIX 12. RENAL CELL CARCINOMA (RCC) 979 -- APPENDIX 12.1. BCR DATA 979 -- Appendix 12.1.1. Descriptive statistics 979 -- Appendix 12.1.2. Uptake of selected drugs 1031 -- APPENDIX 12.2. REIMBURSEMENT CRITERIA FOR SELECTED DRUGS 1033 -- APPENDIX 12.3. MEDICAL LITERATURE: SEARCH FOR EVIDENCE 1037 -- Appendix 12.3.1. Search medical literature (systematic reviews) 1037 -- Appendix 12.3.2. Critical appraisal systematic reviews 1043 -- Appendix 12.3.3. Search strategy 1045 -- APPENDIX 12.4. ECONOMIC LITERATURE 1054 -- Appendix 12.4.1. Search economic literature (HTA reports) 1054 -- Appendix 12.4.2. Results economic literature (HTA reports) 1057 -- APPENDIX 13. OVERVIEW FINDINGS MEDICAL LITERATURE 1083 -- APPENDIX 14. DRUG PRICES 1094 -- APPENDIX 14.1. BREAST CANCER 1095 -- APPENDIX 14.2. CHRONIC MYELOID LEUKAEMIA (CML) 1097 -- APPENDIX 14.3. COLORECTAL CANCER 1100 -- APPENDIX 14.4. HEAD AND NECK CANCER 1102 -- APPENDIX 14.5. MELANOMA 1103 -- APPENDIX 14.6. MESOTHELIOMA 1105 -- APPENDIX 14.7. MULTIPLE MYELOMA 1106 -- APPENDIX 14.8. NON-HODGKIN LYMPHOMA (NHL) 1108 -- APPENDIX 14.9. NON-SMALL-CELL LUNG CARCINOMA (NSCLC). 1110 -- APPENDIX 14.10. OVARIAN CANCER 1112 -- APPENDIX 14.11. PROSTATE CANCER 1114 -- APPENDIX 14.12. RENAL CELL CARCINOMA 1115 Link for e-copy: https://doi.org/10.57598/R343S Format of e-copy: PDF (13,11 Mb) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=4749
ISSN : D/2011/10273/90 : € 0,00
Studie : 2010-03-02
Languages : English (eng) Dutch (nla)
Descriptors: Classification
WP 870 - Breast - - Neoplasms
Indexation
2010-03-02 ; Breast Neoplasms ; Early Detection of Cancer ; Magnetic Resonance Imaging ; Mammography ; Mass Screening ; R172 ; Risk Assessment ; Risk Factors ; Ultrasonography, MammaryAbstract: Alle vrouwen in België tussen 50 en 69 jaar worden 1 maal om de 2 jaar door de overheid uitgenodigd voor een borstonderzoek met mammografie. Het Federaal Kenniscentrum voor de Gezondheidszorg (KCE) oordeelde in 2010 (KCE-rapport 129) dat het niet opportuun was om deze georganiseerde borstkankerscreening uit te breiden naar vrouwen vanaf 40 jaar.
Bij vrouwen met een verhoogd risico kan een vervroegde screening wel een optie zijn. Dit verhoogde risico , de frequentie en methode van screenen worden best op een gestandaardiseerde manier bepaald. Voor vrouwen zonder hoger risico op borstkanker volstaat de georganiseerde borstkankerscreening. Veel vrouwen laten zich screenen buiten het officiële programma. Vaak wordt daarbij systematisch een echografie uitgevoerd, die meestal geen meerwaarde biedt en zorgt voor onnodige extra onderzoeken en ongerustheid.
Link for e-copy: https://doi.org/10.57598/R172A Format of e-copy: PDF [Open Access](3,01 MB) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=2896 Copies
Barcode Call number Media type Location Section Status No copy
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