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Author Gert De Meerleer |
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National practice guideline on the treatment of localised prostate cancer / Bertrand Tombal / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2014)
National practice guideline on the treatment of localised prostate cancer : part 2 [printed text] / Bertrand Tombal, Author ; Anja Desomer, Author ; Pascale Jonckheer , Author ; Geneviève Veereman, Author ; Chris D'Hont, Author ; Roland Van Velthoven, Author ; Axel Feyaerts, Author ; Dirk Schrijvers, Author ; Thierry Gil, Author ; Laurette Renard, Author ; Gert De Meerleer, Author ; Sandrine Rorive, Author ; Bram Spinnewijn,, Author ; Alain Servaes, Author ; Nancy Van Damme, Author ; Hans Van Brabandt , Author . - Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre, 2014 . - 91 p. : Ill., ; A4. - (KCE Reports. Good Clinical Practice (GCP); 226C) .
ISSN : D/2014/10.273/53 : € 0,00
Study n° 2011-01-02
Languages : English (eng)
Descriptors: Classification
WJ 762 Prostatic Neoplasms
Indexation
2011-01-02 ; Prostatectomy ; Prostatic Neoplasms ; R226 ; RadiotherapyContents note: SCIENTIFIC REPORT 9 -- 1 INTRODUCTION 9 -- 1.1 BACKGROUND 9 -- 1.2 THE NEED FOR A GUIDELINE 9 -- 1.3 OVERALL OBJECTIVES 9 -- 1.4 TARGET USERS OF THE GUIDELINE 10 -- 1.5 SCOPE 10 -- 1.5.1 TNM classification of prostate cancer 10 -- 1.5.2 Risk stratification of prostate cancer 10 -- 1.5.3 Scope of the present guideline 11 -- 1.6 STATEMENT OF INTENT 11 -- 1.7 FUNDING AND DECLARATION OF INTEREST 12 -- 2 RECOMMENDATIONS 13 -- 2.1 PATIENT INFORMATION 13 -- 2.2 RADICAL TREATMENT 13 -- 2.3 HIGH INTENSITY FOCUSED ULTRASOUND (HIFU) 14 -- 2.4 HORMONES IN MONO-THERAPY.. 14 -- 3 ALGORITHM 15 -- 4 METHODOLOGY 16 -- 4.1 THE GUIDELINE DEVELOPMENT GROUP (GDG), AUTHORS, EXTERNAL EXPERTS AND STAKEHOLDERS 16 -- 4.2 CLINICAL RESEARCH QUESTIONS 16 -- 4.3 GENERAL APPROACH OF THE GUIDELINE PRODUCTION 19 -- 4.4 SEARCH FOR EXISTING PRACTICE GUIDELINES 19 -- 4.4.1 Search strategy 19 -- 4.4.2 Quality appraisal 19 -- 4.4.3 Source Guideline: the 2014 NICE Prostate Cancer Guideline 20 -- 4.5 SEARCH FOR EVIDENCE FOR DE NOVO RECOMMENDATIONS 21 -- 4.5.1 Study design and date limits 21 -- 4.5.2 Databases 21 -- 4.5.3 Search strategy 22 -- 4.5.4 Quality appraisal 22 -- 4.5.5 Data extraction 22 -- 4.6 GRADING THE QUALITY OF THE EVIDENCE (LEVEL OF EVIDENCE – LOE) 22 -- 4.6.1 Quality of evidence of de novo recommendations 22 -- 4.6.2 Quality of evidence of adapted recommendations 25 -- 4.7 FORMULATION OF RECOMMENDATIONS 25 -- 4.8 GRADING THE STRENGTH OF RECOMMENDATION (SOR) 25 -- 4.9 LAY-OUT OF CHAPTERS DESCRIBING THE RECOMMENDATIONS ADAPTATION PROCESS. 28 -- 4.10 EXTERNAL REVIEW AND STAKEHOLDERS INVOLVEMENT 28 -- 4.10.1 Healthcare professionals 29 -- 4.10.2 Patient representatives 29 -- 4.11 FINAL VALIDATION 29 -- 5 EXTRACT FROM PART-1 OF THE BELGIAN PROSTATE CANCER GUIDELINE 29 -- 6 RECOMMENDATIONS ON PATIENT INFORMATION 30 -- 6.1 SEXUAL DYSFUNCTION AFTER TREATMENT 30 -- 6.1.1 NICE’s Systematic Review, assessment and recommendations 30 -- 6.1.2 Belgian GDG Assessment 30 -- 6.1.3 Stakeholders considerations 30 -- 6.2 URINARY AND GASTRO-INTESTINAL ADVERSE EFFECTS OF TREATMENT 31 -- 6.2.1 NICE’s Systematic Review, assessment and recommendations 31 -- 6.2.2 Belgian GDG Assessment 31 -- 6.2.3 Stakeholders considerations 32 -- 6.3 COLORECTAL CANCER AFTER RADIOTHERAPY 32 -- 6.3.1 NICE’s Systematic Review, assessment and recommendations 32 -- 6.3.2 Belgian GDG Assessment 33 -- 6.3.3Stakeholders considerations 33 -- 6.4 SOCIO-ECONOMIC ASPECTS OF RADICAL TREATMENT 34 -- 7 RECOMMENDATIONS ON RADICAL TREATMENT 34 -- 7.1 RADICAL SURGERY AND RADICAL RADIOTHERAPY 34 -- 7.1.1 NICE’s Systematic Review, assessment and recommendations 34 -- 7.1.2 Belgian GDG Assessment 35 -- 7.2 RADICAL SURGERY 37 -- 7.2.1 NICE’s Systematic Review, assessment and recommendations 37 -- 7.2.2 Belgian GDG Assessment 39 -- 7.3 ADJUVANT HORMONAL THERAPY AFTER RADICAL SURGERY 40 -- 7.3.1 NICE’s Systematic Review, assessment and recommendation 41 -- 7.3.2 Belgian GDG Assessment 41 -- 7.4 RADICAL EXTERNAL BEAM RADIOTHERAPY 42 -- 7.4.1 NICE’s Systematic Review, assessment and recommendations 42 -- 7.4.2 Belgian GDG Assessment 42 -- 7.5 COMBINED EXTERNAL BEAM RADIOTHERAPY AND BRACHYTHERAPY 43 -- 7.5.1 NICE’s Systematic Review, assessment and recommendation 43 -- 7.5.2 Belgian GDG Assessment 45 -- 7.6 RADICAL RADIOTHERAPY COMBINED WITH ANDROGEN DEPRIVATION THERAPY 46 -- 7.6.1 NICE’s Systematic Review, assessment and recommendation on the combination of external beam radiotherapy and hormones 46 -- 7.6.2 Belgian GDG Assessment 48 -- 7.7 OPTIMAL DURATION OF HORMONE THERAPY COMBINED WITH EXTERNAL BEAM RADIOTHERAPY 48 -- 7.7.1 NICE’s Systematic review, assessment and recommendations 49 -- 7.7.2 Belgian GDG Assessment 51 -- 8 HIFU 52 -- 8.1 BACKGROUND 52 -- 8.2 LITERATURE SEARCH RESULTS 53 -- 8.2.1 Systematic reviews 54 -- 8.2.2 Primary studies 54 -- 8.3 GDG CONCLUSIONS 63 -- 8.4 STAKEHOLDERS’ CONSIDERATIONS 63 -- 9 HORMONES IN MONO-THERAPY 64 -- 9.1 BACKGROUND 64 -- 9.2 LITERATURE SEARCH RESULTS 64 -- 9.2.1 Systematic reviews 66 -- 9.2.2 Randomised controlled trials 66 -- 9.3 EVIDENCE SUPPORTING THE USE OF HORMONE-THERAPY IN LOCALISED PROSTATE CANCER 66 -- 9.3.1 Hormone versus placebo 66 -- 9.3.2 Hormone versus hormone 69 -- 9.3.3 Hormone versus hormone + radiotherapy 73 -- 9.4 GDG CONCLUSIONS 75 -- 9.5 STAKEHOLDERS CONSIDERATIONS 75 -- 10 IMPLEMENTATION AND UPDATING OF THIS GUIDELINE 76 -- 10.1 IMPLEMENTATION 76 -- 10.1.1 Multidisciplinary approach 76 -- 10.1.2 Patient-centred care 76 -- 10.1.3 Barriers and facilitators for implementation of this guideline 76 -- 10.1.4 Actors of the implementation of this guideline 76 -- 10.2 MONITORING QUALITY OF CARE 77 -- 10.3 GUIDELINE UPDATE 77 -- REFERENCES 78 Link for e-copy: https://doi.org/10.57598/R226C Format of e-copy: PDF (1,13 Mb) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=3398 Copies(0)
Status No copy National practice guideline on the treatment of localised prostate cancer / Bertrand Tombal / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2014)
National practice guideline on the treatment of localised prostate cancer : part 2 - Appendix [printed text] / Bertrand Tombal, Author ; Anja Desomer, Author ; Pascale Jonckheer , Author ; Geneviève Veereman, Author ; Chris D'Hont, Author ; Roland Van Velthoven, Author ; Axel Feyaerts, Author ; Dirk Schrijvers, Author ; Thierry Gil, Author ; Laurette Renard, Author ; Gert De Meerleer, Author ; Sandrine Rorive, Author ; Bram Spinnewijn,, Author ; Alain Servaes, Author ; Nancy Van Damme, Author ; Hans Van Brabandt , Author . - Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre, 2014 . - 170 p. : Ill., ; A4. - (KCE Reports. Good Clinical Practice (GCP); 226S) .
ISSN : D/2014/10.273/54 : € 0,00
Study n° 2011-01-02
Languages : English (eng)
Descriptors: Classification
WJ 762 Prostatic Neoplasms
Indexation
2011-01-02 ; Prostatectomy ; Prostatic Neoplasms ; R226 ; RadiotherapyContents note: APPENDIX REPORT 1 -- TABLE OF CONTENTS 1 -- LIST OF FIGURES 3 -- LIST OF TABLES 3 -- 1. COMPOSITION OF THE GUIDELINE DEVELOPMENT GROUP 4 -- 1.1. ORIGINAL LIST OF POTENTIAL GDG MEMBERS PROPOSED BY THE COLLEGE FOR ONCOLOGY 4 -- 1.2. COMPOSITION OF THE GUIDELINE DEVELOPMENT GROUP 6 -- 1.3. LIST OF EXTERNAL EXPERTS 6 -- 1.4. COMPOSITION OF THE KCE EXPERT TEAM 7 -- 1.5. LIST OF STAKEHOLDERS 7 -- 1.6. ACKNOWLEDGEMENTS 8 -- 2. SEARCH STRATEGIES 8 -- 2.1. SEARCH STRATEGY FOR GUIDELINES 8 -- 2.1.1. Searched guideline websites and websites of oncologic organizations 8 -- 2.1.2. Standardized search strategy for CPGs in Medline (Ovid) 9 -- 2.2. SEARCH STRATEGIES FOR OTHER PUBLICATIONS (SYSTEMATIC REVIEWS, METAANALYSES, INDIVIDUAL STUDIES) 10 -- 2.2.1. Search strategies for HIFU 10 -- 2.2.2. Search strategies for hormones in mono-therapy 13 -- 3. SEARCH RESULTS 26 -- 3.1. QUALITY APPRAISAL TOOLS 26 -- 3.1.1. Guidelines 26 -- 3.1.2. Systematic reviews 27 -- 3.1.3. Primary studies for therapeutic interventions 29 -- 3.2. GUIDELINES SELECTION AND QUALITY APPRAISAL 31 -- 3.3. SELECTION OF STUDIES AND QUALITY APPRAISAL FOR HIFU 35 -- 3.3.1. Selection and quality appraisal of systematic reviews 35 -- 3.3.2. Selection and quality appraisal of primary studies 38 -- 3.4. SELECTION OF STUDIES AND QUALITY APPRAISAL FOR HORMONE THERAPY IN MONOTHERAPY 40 -- 3.4.1. Selection and quality appraisal of selected systematic reviews 40 -- 3.4.2. Selection and quality appraisal of primary studies 48 -- 4. EVIDENCE TABLES BY CLINICAL QUESTION 51 -- 4.1. HIFU 51 -- 4.1.1. Evidence tables of systematic reviews on HIFU 51 -- 4.1.2. Evidence tables of primary studies on HIFU 52 -- 4.2. HORMONE THERAPY IN MONOTHERAPY 80 -- 4.2.1. Evidence tables of systematic reviews on hormone therapy 80 -- 4.2.2. Evidence tables of primary studies on hormone therapy 80 -- 5. EXTERNAL REVIEW 132 -- 5.1. EVALUATION OF THE RECOMMENDATIONS GDG2 132 -- 5.2. EVALUATION OF THE RECOMMENDATIONS GDG3 136 -- 5.3. EVALUATION OF THE RECOMMENDATIONS STAKEHOLDERS AND GDG4 139 -- 5.4. FINAL VERSION OF THE BELGIAN RECOMMENDATIONS AS COMPARED WITH NICE’S GUIDELINE 142 -- REFERENCES 144 Link for e-copy: https://doi.org/10.57598/R226S Format of e-copy: PDF (932 Kb) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=3400 Copies(0)
Status No copy National practice guideline on the treatment of localised prostate cancer / Bertrand Tombal / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2014)
Copies(0)
Status No copy Nationale praktijkrichtlijn voor de behandeling van gelokaliseerde prostaatkanker / Bertrand Tombal / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2014)
Nationale praktijkrichtlijn voor de behandeling van gelokaliseerde prostaatkanker : deel 2 - Synthese [printed text] / Bertrand Tombal, Author ; Anja Desomer, Author ; Pascale Jonckheer , Author ; Geneviève Veereman, Author ; Chris D'Hont, Author ; Roland Van Velthoven, Author ; Axel Feyaerts, Author ; Dirk Schrijvers, Author ; Thierry Gil, Author ; Laurette Renard, Author ; Gert De Meerleer, Author ; Sandrine Rorive, Author ; Bram Spinnewijn,, Author ; Alain Servaes, Author ; Nancy Van Damme, Author ; Hans Van Brabandt , Author . - Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre, 2014 . - 16 p. : Ill., ; A4. - (KCE Reports A. Good Clinical Practice (GCP); 226AS) .
ISSN : D/2014/10.273/50 : € 0,00
Studie n° 2011-01-02
Languages : Dutch (nla)
Descriptors: Classification
WJ 762 Prostatic Neoplasms
Indexation
2011-01-02 ; Prostatectomy ; Prostatic Neoplasms ; R226 ; RadiotherapyAbstract: Het Federaal Kenniscentrum voor de Gezondheidszorg (KCE) en het College voor Oncologie brachten de recentste wetenschappelijke bevindingen samen over de behandeling van een niet uitgezaaide prostaatkanker. Uit een vorig rapport bleek dat er voor de minst agressieve vormen van kanker niet steeds meteen iets gedaan moet worden en dat men een afwachtende houding kan aannemen. Bij meer ernstige vormen is het verwijderen van de prostaat (prostatectomie) en radiotherapie aangewezen. Het gebruik van hormonen zonder meer wordt bij lokale kankers formeel afgeraden, want dit werkt eerder nadelig en kan de levensverwachting van de patiënt inkorten. Omdat de werkzaamheid van een behandeling met hoogfrequente geluidsgolven (HIFU) nog onvoldoende wetenschappelijk onderbouwd is, beveelt het KCE aan om deze behandeling enkel uit te voeren in het kader van klinische studies. Link for e-copy: https://doi.org/10.57598/R226AS Format of e-copy: PDF (443 Kb) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=3401 Copies(0)
Status No copy Recommandations nationales de bonne pratique pour la prise en charge du cancer localisé de la prostate / Bertrand Tombal / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2014)
Recommandations nationales de bonne pratique pour la prise en charge du cancer localisé de la prostate : seconde partie - Synthèse [printed text] / Bertrand Tombal, Author ; Anja Desomer, Author ; Pascale Jonckheer , Author ; Geneviève Veereman, Author ; Chris D'Hont, Author ; Roland Van Velthoven, Author ; Axel Feyaerts, Author ; Dirk Schrijvers, Author ; Thierry Gil, Author ; Laurette Renard, Author ; Gert De Meerleer, Author ; Sandrine Rorive, Author ; Bram Spinnewijn,, Author ; Alain Servaes, Author ; Nancy Van Damme, Author ; Hans Van Brabandt , Author . - Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre, 2014 . - 16 p. : Ill., ; A4. - (KCE Reports B. Good Clinical Practice (GCP); 226BS) .
ISSN : D/2014/10.273/51 : € 0,00
Etude n° 2011-01-02
Languages : French (fre)
Descriptors: Classification
WJ 762 Prostatic Neoplasms
Indexation
2011-01-02 ; Prostatectomy ; Prostatic Neoplasms ; R226 ; RadiotherapyAbstract: Le Centre Fédéral d’Expertise des Soins de Santé (KCE) et le Collège d’Oncologie ont examiné les avancées les plus récentes en matière de traitement des cancers localisés, non métastasés, de la prostate. Un précédent rapport indiquait que, face aux formes les moins agressives de ce cancer, il ne fallait pas nécessairement intervenir tout de suite et que l’on pouvait se contenter de surveiller son évolution. Dans les formes à risque plus élevé, l’ablation de la prostate(prostatectomie) et la radiothérapie restent indiquées. Le traitement par hormonothérapie seule est formellement contre-indiqué dans les cancers localisés car ce traitement a des effets secondaires et pourrait raccourcir l’espérance de vie des hommes traités. En ce qui concerne le traitement par ultrasons (HIFU), en l’absence de nouvelles preuves scientifiques quant à son efficacité, le KCE recommande que ce traitement ne soit pratiqué que dans le cadre d’études cliniques. Link for e-copy: https://doi.org/10.57598/R226BS Format of e-copy: PDF (440 Kb) Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=3402 Copies(0)
Status No copy Soutien scientifique au Collège d’Oncologie / Bertrand Tombal / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2010)
PermalinkWetenschappelijke ondersteuning van het College voor Oncologie / Bertrand Tombal / Brussels [Belgium] : KCE = Federaal Kenniscentrum voor de Gezondheidszorg = Centre Fédéral d'Expertise des Soins de Santé = Belgian Health Care Knowledge Centre (2010)
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