Author Gregory Duchscherer
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Safety and efficacy of inhaled nitric oxide in the management of Hypoxemic respiratory failure in adults with acute respiratory distress syndrome / Gregory Duchscherer / Alberta [Canada] : Institute of Health Economics (2007)
Safety and efficacy of inhaled nitric oxide in the management of Hypoxemic respiratory failure in adults with acute respiratory distress syndrome [printed text] / Gregory Duchscherer, Author ; Bing Guo, Author . - Alberta [Canada] : Institute of Health Economics, 2007 . - x, 65 p. : ill. ; A5. - (IHE Report, ISSN 1710-6605) .
ISBN : 978-0-9780024-9-7 : 0
This report was prepared in collaboration with the Health Technology Assessment program of the Institute of Heath Economics, SEARCH Canada, and Calgary Health Region. It focuses on the published scientific evidence regarding the safety and efficacy of inhaled Nitric Oxide (iNO) in the management of hypoxemic respiratory failure in adult patients
with acute respiratory distress syndrome (ARDS). This report also includes local context data from the Calgary Health Region regarding outcomes from ARDS, and utilization of iNO therapy.
The purpose of this report is to examine the scientific evidence on the use of iNO in this population with the goal of producing new insights regarding the optimal use of this experimental therapy.
Languages : English (eng)
WF 600 Diseases of the Respiratory System - Lungs
Canada ; Nitric Oxide ; Respiratory Distress Syndrome, Adult ; Respiratory Insufficiency ; Technology Assessment, Biomedical ; Therapy
Contents note: Acknowledgments i -- Competing Interest ii -- Executive Summary iv -- Glossary vi -- Abbreviations vii -- Table of Contents ix -- Introduction 1 -- Background 1 -- Definitions of Acute Lung Injury and ARDS 1 -- Incidence of ARDS 4 -- Etiology of ARDS 4 -- Pathology and Pathophysiology of ARDS 5 -- Prognosis of Patients with ARDS.6 -- Treatment of ARDS 7 -- Nitric Oxide 10 -- Nitric oxide chemical and biochemical interactions 10 -- Rationale for iNO therapy 11 -- Potential complications and safety concerns associated with iNO therapy 2 -- Cost of iNO therapy 13 -- Cost-effectiveness of iNO therapy 14 -- Regulatory Status 14 -- Local Context 15 -- Efficacy Of Inhaled Nitric Oxide In Ali/ards 18 -- Evidence from systematic reviews 18 -- Evidence from randomized controlled trials 21 -- Expert Opinion 27 -- Clinical Guidelines And Ongoing Clinical Trials 28 -- Discussion 29 -- Efficacy 29 -- Safety and Adverse Events 37 -- Cost of iNO therapy 38 -- Summary and Conclusion 38 -- Appendix A: Methodology 40 -- Appendix B: randomized controlled trials data extraction tables 47 -- References 57 -- Tables and Figures -- Figure 1 ICU and hospital mortality with an ARDS diagnosis in the Calgary Health Region 16 -- Figure 2 Total number of patients on iNO therapy per fiscal quarter in the Calgary Health Region 16 -- Figure 3 Total iNO therapy usage per fiscal quarter in the Calgary Health Region 17 -- Figure 4 Average Usage of iNO per patient in the Calgary Health Region 17 -- Figure 5 Quarterly nitric oxide expenditure for the adult ICUs in the Calgary Health Region 18 -- Table 1 Recommended criteria for ALI and ARDS 2 -- Table 2 Components and individual values of the lung injury score 3 -- Table 3 Etiology of ARDS 5 -- Table A.1 Databases and search terms used in the search strategy 40 -- Table B.1 Randomized Controlled Trials Data Extraction Table 47 Link for e-copy: http://www.ihe.ca/documents/IHE_Report_The_Use_of_Nitric_Oxide_in_Acute_Respirat [...] Format of e-copy: PDF (2,7 MB) Record link:
Barcode Call number Media type Location Section Status 10273-01732 WF 600/DUC Book KCE Library (10.124) Not for loan