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A candidate vaccine based on the hepatitis C E1 protein / Leroux-Roels, G in Vaccine, 22(2004)23-24 ([08/13/2004])
[article] A candidate vaccine based on the hepatitis C E1 protein : tolerability and immunogenicity in healthy volunteers [printed text] / Leroux-Roels, G, Author ; E. Depla, Author ; Frank Hulstaert, Author ; L. Tobback, Author ; S. Dincq, Author ; J. Desmet, Author ; I. Desombere, Author ; G. Maertens, Author . - 2004 . - 3080-6.
Languages : English (eng)
in Vaccine > 22(2004)23-24 [08/13/2004] . - 3080-6
Descriptors: Classification
W 1 Serials. Periodicals
Indexation
Adolescent ; Adult ; Antibody Formation ; Hepatitis C ; Humans ; Immunity, Cellular ; Immunization, Secondary ; Injections, Intramuscular ; Interferon-alpha ; Interleukin-5 ; Journal Article ; Lymphocyte Count ; Male ; Middle Aged ; Netherlands ; Peer Review ; T-Lymphocytes ; Vaccines, Synthetic ; Viral Envelope Proteins ; Viral VaccinesAbstract: The tolerability and immunogenicity of the hepatitis C virus E1 protein as a candidate vaccine was examined in a Phase I, single-arm study. Twenty healthy male volunteers were injected in the deltoid muscle at weeks 0, 3 and 6 with 20 microg recombinant E1 adsorbed on alum. A fourth (booster) dose was administered to 19 subjects at week 26. The candidate therapeutic vaccine was well tolerated. Three vaccine doses induced a clear humoral anti-E1 response that was boosted by a fourth dose. A strong, specific cellular immune response towards E1 was elicited in all vaccine recipients, which included a clear Th1 type response in all but one of the subjects. Link for e-copy: http://tiny.cc/l9e3r Format of e-copy: VDIC IP recognition Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=2189 [article]