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Author W. Hellenbrand |
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Strong Public Health Recommendations from Weak Evidence? / Germaine Hanquet in BioMed research international, 2015(2015) ([12/23/2015])
[article] Strong Public Health Recommendations from Weak Evidence? : Lessons Learned in Developing Guidance on the Public Health Management of Meningococcal Disease [printed text] / Germaine Hanquet, Author ; P. Stefanoff, Author ; W. Hellenbrand, Author ; S. Heuberger, Author ; P. Lopalco, Author ; J.M. Stuart, Author . - 2015 . - 11 p.
Languages : English (eng)
in BioMed research international > 2015(2015) [12/23/2015] . - 11 p.
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W 1 Serials. Periodicals
Indexation
Europe ; Humans ; Journal Article ; Meningococcal Infections ; Peer Review ; Public HealthAbstract: The evidence underpinning public health policy is often of low quality, leading to inconsistencies in recommended interventions. One example is the divergence in national policies across Europe for managing contacts of invasive meningococcal disease. Aiming to develop consistent guidance at the European level, a group of experts reviewed the literature and formulated recommendations. The group defined eight priority research questions, searched the literature, and formulated recommendations using GRADE methodology. Five of the research questions are discussed in this paper. After taking into account quality of evidence, benefit, harm, value, preference, burden on patient of the intervention, and resource implications, we made four strong recommendations and five weak recommendations for intervention. Strong recommendations related not only to one question with very low quality of evidence as well as to two questions with moderate to high quality of evidence. The weak recommendations related to two questions with low and very low quality of evidence but also to one question with moderate quality of evidence. GRADE methodology ensures a transparent process and explicit recognition of additional factors that should be considered when making recommendations for policy. This approach can be usefully applied to many areas of public health policy where evidence quality is often low. Link for e-copy: https://files.kce.be/articles/Hanquet G_2015_Biomed Res Int_2015_569235.pdf Format of e-copy: PDF [Open Access] Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=4031 [article]E-copies
Hanquet G_2015_Biomed Res Int_2015_569235.pdfAdobe Acrobat PDF What is the evidence for giving chemoprophylaxis to children or students attending the same preschool, school or college as a case of meningococcal disease? / W. Hellenbrand in Epidemiology and Infection, (2011)Août ([08/11/2011])
[article] What is the evidence for giving chemoprophylaxis to children or students attending the same preschool, school or college as a case of meningococcal disease? [printed text] / W. Hellenbrand, Author ; Germaine Hanquet, Author ; S. Heuberger, Author ; S. Nielsen, Author ; P. Stefanoff, Author ; J.M. Stuart, Author . - 2011 . - pp. 1-8.
Languages : English (eng)
in Epidemiology and Infection > (2011)Août [08/11/2011] . - pp. 1-8
Descriptors: Classification
W 1 Serials. Periodicals
Indexation
Chemoprevention ; Journal Article ; Meningococcal Infections ; Peer Review ; Public HealthAbstract: SUMMARYWe performed a systematic literature review to assess the effectiveness of chemoprophylaxis for contacts of sporadic cases of invasive meningococcal disease (IMD) in educational settings. No studies directly compared IMD risk in contacts with/without chemoprophylaxis. However, compared to the background incidence, an elevated IMD risk was identified in settings without a general recommendation for chemoprophylaxis in pre-schools [pooled risk difference (RD) 58·2/105, 95% confidence interval (CI) 27·3-89·0] and primary schools (pooled RD 4·9/105, 95% CI 2·9-6·9) in the ~30 days after contact with a sporadic IMD case, but not in other educational settings. Thus, limited but consistent evidence suggests the risk of IMD in pre-school contacts of sporadic IMD cases is significantly increased above the background risk, but lower than in household contacts (pooled RD for household contacts with no chemoprophylaxis vs. background incidence: 480·1/105, 95% CI 321·5-639·9). We recommend chemoprophylaxis for pre-school contacts depending on an assessment of duration and closeness of contact. Link for e-copy: http://vdic.idm.oclc.org/login?url=http://journals.cambridge.org/action/displayA [...] Format of e-copy: VDIC IP recognition Record link: https://kce.docressources.info/index.php?lvl=notice_display&id=2715 [article]